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- W2123271440 endingPage "a001842" @default.
- W2123271440 startingPage "a001842" @default.
- W2123271440 abstract "A major goal of modern neuroscience research is to understand the cellular and molecular processes that control the formation, function, and remodeling of chemical synapses. In this article, we discuss the numerous studies that implicate molecules initially discovered for their functions in axon guidance as critical regulators of synapse formation and plasticity. Insights from these studies have helped elucidate basic principles of synaptogenesis, dendritic spine formation, and structural and functional synapse plasticity. In addition, they have revealed interesting dual roles for proteins and cellular mechanisms involved in both axon guidance and synaptogenesis. Much like the dual involvement of morphogens in early cell fate induction and axon guidance, many guidance-related molecules continue to play active roles in controlling the location, number, shape, and strength of neuronal synapses during development and throughout the lifetime of the organism. This article summarizes key findings that link axon guidance molecules to specific aspects of synapse formation and plasticity and discusses the emerging relationship between the molecular and cellular mechanisms that control both axon guidance and synaptogenesis." @default.
- W2123271440 created "2016-06-24" @default.
- W2123271440 creator A5021887669 @default.
- W2123271440 creator A5067304730 @default.
- W2123271440 date "2010-03-10" @default.
- W2123271440 modified "2023-10-18" @default.
- W2123271440 title "Guidance Molecules in Synapse Formation and Plasticity" @default.
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