Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123274611> ?p ?o ?g. }
- W2123274611 endingPage "57" @default.
- W2123274611 startingPage "49" @default.
- W2123274611 abstract "Allergic bronchopulmonary aspergillosis (ABPA) is a virulent manifestation of the Th2 asthma endotype that includes asthma with fungal sensitization, raising the feasibility of biological therapies targeting Th2 pathway molecules or cells. The first molecule amenable to clinical intervention with a biological was IgE. Omalizumab, a humanized monoclonal antibody (Mab), targets the same epitope on the IgE CH3 region that binds to and crosslinks high‐affinity receptors on mast cells and basophils, thereby initiating the allergic inflammatory cascade. Omalizumab is licensed for allergic asthma and has been beneficial in uncontrolled studies of ABPA, reducing exacerbations and steroid requirements. Trials of several Mabs directed against the Th2 cytokine IL‐5 show clinical benefit in patients with a severe refractory eosinophilic asthma phenotype, while a Mab against IL‐13 is effective in asthma patients with a Th2‐high endotype. Immunodulation is also feasible with small molecule biologicals, such as antisense oligodeoxynucleotides and cholecalciferol. Controlled trials of Th2‐inhibiting biologicals in patients with ABPA and severe asthma with fungal sensitization appear warranted." @default.
- W2123274611 created "2016-06-24" @default.
- W2123274611 creator A5022053553 @default.
- W2123274611 date "2012-12-01" @default.
- W2123274611 modified "2023-09-26" @default.
- W2123274611 title "The use of biological agents for the treatment of fungal asthma and allergic bronchopulmonary aspergillosis" @default.
- W2123274611 cites W1493815102 @default.
- W2123274611 cites W1501205955 @default.
- W2123274611 cites W1521605576 @default.
- W2123274611 cites W1579720523 @default.
- W2123274611 cites W1916962812 @default.
- W2123274611 cites W1947099084 @default.
- W2123274611 cites W1964208379 @default.
- W2123274611 cites W1967215794 @default.
- W2123274611 cites W1981080045 @default.
- W2123274611 cites W1983832849 @default.
- W2123274611 cites W1985927542 @default.
- W2123274611 cites W1987444459 @default.
- W2123274611 cites W1987553199 @default.
- W2123274611 cites W1988758075 @default.
- W2123274611 cites W1989823290 @default.
- W2123274611 cites W1990654889 @default.
- W2123274611 cites W1995784152 @default.
- W2123274611 cites W2002292213 @default.
- W2123274611 cites W2008719700 @default.
- W2123274611 cites W2008931469 @default.
- W2123274611 cites W2008945707 @default.
- W2123274611 cites W2009987865 @default.
- W2123274611 cites W2010962160 @default.
- W2123274611 cites W2016058269 @default.
- W2123274611 cites W2018370210 @default.
- W2123274611 cites W2021701428 @default.
- W2123274611 cites W2025111901 @default.
- W2123274611 cites W2029587541 @default.
- W2123274611 cites W2031467805 @default.
- W2123274611 cites W2034519404 @default.
- W2123274611 cites W2035632341 @default.
- W2123274611 cites W2041325078 @default.
- W2123274611 cites W2041651163 @default.
- W2123274611 cites W2047492352 @default.
- W2123274611 cites W2051235592 @default.
- W2123274611 cites W2061775758 @default.
- W2123274611 cites W2062918919 @default.
- W2123274611 cites W2063908767 @default.
- W2123274611 cites W2067324660 @default.
- W2123274611 cites W2070182900 @default.
- W2123274611 cites W2084370208 @default.
- W2123274611 cites W2088225529 @default.
- W2123274611 cites W2093711396 @default.
- W2123274611 cites W2097981132 @default.
- W2123274611 cites W2098968578 @default.
- W2123274611 cites W2099211356 @default.
- W2123274611 cites W2103541662 @default.
- W2123274611 cites W2106117449 @default.
- W2123274611 cites W2106715003 @default.
- W2123274611 cites W2108919922 @default.
- W2123274611 cites W2110052844 @default.
- W2123274611 cites W2110500887 @default.
- W2123274611 cites W2111792628 @default.
- W2123274611 cites W2115268249 @default.
- W2123274611 cites W2118489978 @default.
- W2123274611 cites W2121195755 @default.
- W2123274611 cites W2123330148 @default.
- W2123274611 cites W2126870687 @default.
- W2123274611 cites W2127482775 @default.
- W2123274611 cites W2129228230 @default.
- W2123274611 cites W2130464360 @default.
- W2123274611 cites W2132166755 @default.
- W2123274611 cites W2135243535 @default.
- W2123274611 cites W2139618618 @default.
- W2123274611 cites W2140496450 @default.
- W2123274611 cites W2142637315 @default.
- W2123274611 cites W2146852572 @default.
- W2123274611 cites W2147711737 @default.
- W2123274611 cites W2148750103 @default.
- W2123274611 cites W2149810044 @default.
- W2123274611 cites W2150035260 @default.
- W2123274611 cites W2152563928 @default.
- W2123274611 cites W2154159315 @default.
- W2123274611 cites W2157566717 @default.
- W2123274611 cites W2159320790 @default.
- W2123274611 cites W2160953471 @default.
- W2123274611 cites W2164891490 @default.
- W2123274611 cites W2164979744 @default.
- W2123274611 cites W2168523148 @default.
- W2123274611 cites W2170886637 @default.
- W2123274611 cites W2315018741 @default.
- W2123274611 cites W4211215838 @default.
- W2123274611 cites W4241493931 @default.
- W2123274611 doi "https://doi.org/10.1111/j.1749-6632.2012.06810.x" @default.
- W2123274611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23231714" @default.
- W2123274611 hasPublicationYear "2012" @default.
- W2123274611 type Work @default.
- W2123274611 sameAs 2123274611 @default.
- W2123274611 citedByCount "26" @default.
- W2123274611 countsByYear W21232746112013 @default.
- W2123274611 countsByYear W21232746112014 @default.
- W2123274611 countsByYear W21232746112015 @default.