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- W2123277537 endingPage "38" @default.
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- W2123277537 abstract "High-density lipoprotein (HDL) appears to be the dominant lipoprotein particle in human follicular fluid (FF). The reported anti-atherogenic properties of HDL have been attributed in part to reverse cholesterol transport. The discoveries of the scavenger receptor class B type I (SR-BI) and the ATP-binding cassette A1 lipid (ABCA1) transporter have generated studies aimed at unraveling the pathways of HDL biogenesis, remodeling and catabolism. The production of SR-BI and ABCA1 knockout mice as well as other lipoprotein metabolism-associated mutants has resulted in reduced or absent fertility, leading us to postulate the existence of a human hepatic-ovarian HDL-associated axis of fertility. Here, we review an evolving literature on the role of HDL metabolism on mammalian fertility and oocyte development.An extensive online search was conducted of published articles relevant to the section topics discussed. All relevant English language articles contained in Pubmed/Medline, with no specific time frame for publication, were considered for this narrative review. Cardiovascular literature was highly cited due to the wealth of relevant knowledge on HDL metabolism, and the dearth thereof in the reproductive field.Various vertebrate models demonstrate a role for HDL in embryo development and fertility. In our clinical studies, FF levels of HDL cholesterol and apolipoprotein AI levels were negatively associated with embryo fragmentation, but not with embryo cell cleavage rate. However, the HDL component, paraoxonase 1 arylesterase activity, was positively associated with embryo cell cleavage rate.HDL contributes to intra-follicular cholesterol homeostasis which appears to be important for successful oocyte and embryo development." @default.
- W2123277537 created "2016-06-24" @default.
- W2123277537 creator A5009025876 @default.
- W2123277537 creator A5041065499 @default.
- W2123277537 creator A5044982105 @default.
- W2123277537 creator A5049136514 @default.
- W2123277537 creator A5070287812 @default.
- W2123277537 date "2009-08-21" @default.
- W2123277537 modified "2023-09-23" @default.
- W2123277537 title "High-density lipoprotein metabolism and the human embryo" @default.
- W2123277537 cites W1489280123 @default.
- W2123277537 cites W1529009137 @default.
- W2123277537 cites W1536933520 @default.
- W2123277537 cites W1542242159 @default.
- W2123277537 cites W1550247149 @default.
- W2123277537 cites W1564861448 @default.
- W2123277537 cites W1574380753 @default.
- W2123277537 cites W1577273492 @default.
- W2123277537 cites W1591670239 @default.
- W2123277537 cites W1596816338 @default.
- W2123277537 cites W1604097175 @default.
- W2123277537 cites W1607399348 @default.
- W2123277537 cites W162354695 @default.
- W2123277537 cites W1656852118 @default.
- W2123277537 cites W1749716853 @default.
- W2123277537 cites W1765820548 @default.
- W2123277537 cites W1776354881 @default.
- W2123277537 cites W1845720460 @default.
- W2123277537 cites W1860908381 @default.
- W2123277537 cites W1863056418 @default.
- W2123277537 cites W1881366512 @default.
- W2123277537 cites W1958026543 @default.
- W2123277537 cites W1964827297 @default.
- W2123277537 cites W1966792058 @default.
- W2123277537 cites W1966811171 @default.
- W2123277537 cites W1968196140 @default.
- W2123277537 cites W1968883066 @default.
- W2123277537 cites W1969173142 @default.
- W2123277537 cites W1969888007 @default.
- W2123277537 cites W1970673696 @default.
- W2123277537 cites W1972482036 @default.
- W2123277537 cites W1973312680 @default.
- W2123277537 cites W1974660803 @default.
- W2123277537 cites W1974864595 @default.
- W2123277537 cites W1975031054 @default.
- W2123277537 cites W1975466087 @default.
- W2123277537 cites W1975798465 @default.
- W2123277537 cites W1977085017 @default.
- W2123277537 cites W1977321522 @default.
- W2123277537 cites W1981003642 @default.
- W2123277537 cites W1982135704 @default.
- W2123277537 cites W1983126001 @default.
- W2123277537 cites W1983779487 @default.
- W2123277537 cites W1984875752 @default.
- W2123277537 cites W1985170971 @default.
- W2123277537 cites W1986439388 @default.
- W2123277537 cites W1986648162 @default.
- W2123277537 cites W1986755251 @default.
- W2123277537 cites W1986755882 @default.
- W2123277537 cites W1988997346 @default.
- W2123277537 cites W1989928096 @default.
- W2123277537 cites W1990252208 @default.
- W2123277537 cites W1990394752 @default.
- W2123277537 cites W1990807902 @default.
- W2123277537 cites W1993881492 @default.
- W2123277537 cites W1994106242 @default.
- W2123277537 cites W1994483831 @default.
- W2123277537 cites W1996060236 @default.
- W2123277537 cites W1996156489 @default.
- W2123277537 cites W1996180854 @default.
- W2123277537 cites W1996626361 @default.
- W2123277537 cites W1997492405 @default.
- W2123277537 cites W1997678048 @default.
- W2123277537 cites W1998497437 @default.
- W2123277537 cites W2003300810 @default.
- W2123277537 cites W2003532276 @default.
- W2123277537 cites W2004805723 @default.
- W2123277537 cites W2008655428 @default.
- W2123277537 cites W2009636256 @default.
- W2123277537 cites W2010496276 @default.
- W2123277537 cites W2011656212 @default.
- W2123277537 cites W2013282518 @default.
- W2123277537 cites W2015119995 @default.
- W2123277537 cites W2015849111 @default.
- W2123277537 cites W2017905787 @default.
- W2123277537 cites W2018746110 @default.
- W2123277537 cites W2019005804 @default.
- W2123277537 cites W2020095127 @default.
- W2123277537 cites W2020780744 @default.
- W2123277537 cites W2021081987 @default.
- W2123277537 cites W2021446448 @default.
- W2123277537 cites W2021657072 @default.
- W2123277537 cites W2021722496 @default.
- W2123277537 cites W2023426559 @default.
- W2123277537 cites W2025155898 @default.
- W2123277537 cites W2026677644 @default.
- W2123277537 cites W2026808809 @default.
- W2123277537 cites W2030210480 @default.