FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123281538> ?p ?o ?g. }

• W2123281538 endingPage "1414" @default.
• W2123281538 startingPage "1405" @default.
• W2123281538 abstract "The molecular mechanisms that lead to the cognitive defects characteristic of Down syndrome (DS), the most frequent cause of mental retardation, have remained elusive. Here we use a transgenic DS mouse model (152F7 line) to show that DYRK1A gene dosage imbalance deregulates chromosomal clusters of genes located near neuron-restrictive silencer factor (REST/NRSF) binding sites. We found that Dyrk1a binds the SWI/SNF complex known to interact with REST/NRSF. The mutation of a REST/NRSF binding site in the promoter of the REST/NRSF target gene L1cam modifies the transcriptional effect of Dyrk1a-dosage imbalance on L1cam. Dyrk1a dosage imbalance perturbs Rest/Nrsf levels with decreased Rest/Nrsf expression in embryonic neurons and increased expression in adult neurons. Using transcriptome analysis of embryonic brain subregions of transgenic 152F7 mouse line, we identified a coordinated deregulation of multiple genes that are responsible for dendritic growth impairment present in DS. Similarly, Dyrk1a overexpression in primary mouse cortical neurons induced severe reduction of the dendritic growth and dendritic complexity. We propose that DYRK1A overexpression-related neuronal gene deregulation via disturbance of REST/NRSF levels, and the REST/NRSF-SWI/SNF chromatin remodelling complex, significantly contributes to the neural phenotypic changes that characterize DS." @default.
• W2123281538 created "2016-06-24" @default.
• W2123281538 creator A5001925972 @default.
• W2123281538 creator A5004711419 @default.
• W2123281538 creator A5008529334 @default.
• W2123281538 creator A5009213067 @default.
• W2123281538 creator A5011433642 @default.
• W2123281538 creator A5013905067 @default.
• W2123281538 creator A5017363465 @default.
• W2123281538 creator A5022177128 @default.
• W2123281538 creator A5028532301 @default.
• W2123281538 creator A5029619328 @default.
• W2123281538 creator A5038113594 @default.
• W2123281538 creator A5047227653 @default.
• W2123281538 creator A5048460180 @default.
• W2123281538 creator A5050648891 @default.
• W2123281538 creator A5053037165 @default.
• W2123281538 creator A5057486984 @default.
• W2123281538 creator A5060853708 @default.
• W2123281538 creator A5064197619 @default.
• W2123281538 creator A5070751198 @default.
• W2123281538 creator A5071702929 @default.
• W2123281538 creator A5078209887 @default.
• W2123281538 creator A5089138613 @default.
• W2123281538 creator A5090649307 @default.
• W2123281538 date "2009-02-12" @default.
• W2123281538 modified "2023-10-17" @default.
• W2123281538 title "DYRK1A interacts with the REST/NRSF-SWI/SNF chromatin remodelling complex to deregulate gene clusters involved in the neuronal phenotypic traits of Down syndrome" @default.
• W2123281538 cites W1816072488 @default.
• W2123281538 cites W1884108341 @default.
• W2123281538 cites W1964318436 @default.
• W2123281538 cites W1964385320 @default.
• W2123281538 cites W1968849378 @default.
• W2123281538 cites W1974950833 @default.
• W2123281538 cites W1976241604 @default.
• W2123281538 cites W1980958817 @default.
• W2123281538 cites W1981155642 @default.
• W2123281538 cites W2006124071 @default.
• W2123281538 cites W2007289852 @default.
• W2123281538 cites W2013444425 @default.
• W2123281538 cites W2024526487 @default.
• W2123281538 cites W2036475318 @default.
• W2123281538 cites W2040150222 @default.
• W2123281538 cites W2044046427 @default.
• W2123281538 cites W2057892969 @default.
• W2123281538 cites W2060733408 @default.
• W2123281538 cites W2072930008 @default.
• W2123281538 cites W2078518864 @default.
• W2123281538 cites W2097220641 @default.
• W2123281538 cites W2112197800 @default.
• W2123281538 cites W2120580225 @default.
• W2123281538 cites W2129795133 @default.
• W2123281538 cites W2134953810 @default.
• W2123281538 cites W2136381888 @default.
• W2123281538 cites W2137082708 @default.
• W2123281538 cites W2148386452 @default.
• W2123281538 cites W2153932747 @default.
• W2123281538 cites W2160649479 @default.
• W2123281538 cites W2163154029 @default.
• W2123281538 cites W2169123716 @default.
• W2123281538 doi "https://doi.org/10.1093/hmg/ddp047" @default.
• W2123281538 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19218269" @default.
• W2123281538 hasPublicationYear "2009" @default.
• W2123281538 type Work @default.
• W2123281538 sameAs 2123281538 @default.
• W2123281538 citedByCount "118" @default.
• W2123281538 countsByYear W21232815382012 @default.
• W2123281538 countsByYear W21232815382013 @default.
• W2123281538 countsByYear W21232815382014 @default.
• W2123281538 countsByYear W21232815382015 @default.
• W2123281538 countsByYear W21232815382016 @default.
• W2123281538 countsByYear W21232815382017 @default.
• W2123281538 countsByYear W21232815382018 @default.
• W2123281538 countsByYear W21232815382019 @default.
• W2123281538 countsByYear W21232815382020 @default.
• W2123281538 countsByYear W21232815382021 @default.
• W2123281538 countsByYear W21232815382022 @default.
• W2123281538 countsByYear W21232815382023 @default.
• W2123281538 crossrefType "journal-article" @default.
• W2123281538 hasAuthorship W2123281538A5001925972 @default.
• W2123281538 hasAuthorship W2123281538A5004711419 @default.
• W2123281538 hasAuthorship W2123281538A5008529334 @default.
• W2123281538 hasAuthorship W2123281538A5009213067 @default.
• W2123281538 hasAuthorship W2123281538A5011433642 @default.
• W2123281538 hasAuthorship W2123281538A5013905067 @default.
• W2123281538 hasAuthorship W2123281538A5017363465 @default.
• W2123281538 hasAuthorship W2123281538A5022177128 @default.
• W2123281538 hasAuthorship W2123281538A5028532301 @default.
• W2123281538 hasAuthorship W2123281538A5029619328 @default.
• W2123281538 hasAuthorship W2123281538A5038113594 @default.
• W2123281538 hasAuthorship W2123281538A5047227653 @default.
• W2123281538 hasAuthorship W2123281538A5048460180 @default.
• W2123281538 hasAuthorship W2123281538A5050648891 @default.
• W2123281538 hasAuthorship W2123281538A5053037165 @default.
• W2123281538 hasAuthorship W2123281538A5057486984 @default.
• W2123281538 hasAuthorship W2123281538A5060853708 @default.
• W2123281538 hasAuthorship W2123281538A5064197619 @default.
• W2123281538 hasAuthorship W2123281538A5070751198 @default.

• next