Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123319065> ?p ?o ?g. }
- W2123319065 endingPage "373" @default.
- W2123319065 startingPage "364" @default.
- W2123319065 abstract "Reversibly stabilized DNA nanoparticles (rSDN) were prepared by coating reducible polycation/DNA complexes with multivalent N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers. RGD-targeted rSDN were formulated by linking cyclic c(RGDyK) to the surface layer of rSDN. Cellular uptake in B16F10 mouse melanoma cells, human umbilical vein endothelial cells (HUVEC), and THLE immortalized hepatic cells was quantified by real-time PCR. RGD-targeted rSDN exhibited approximately twofold higher cell uptake in integrin-positive cells: B16F10 and HUVEC compared to THLE cells with low integrin content. RGD-targeting mediated increased transfection activity in B16F10 cells but not in THLE cells. Overall, the studies show that rSDN can be effectively targeted with RGD while exhibiting reduced nonspecific cell interactions and favorable stability. As such, these gene delivery vectors have the potential to permit targeting therapeutic genes to tumors by systemic delivery. In addition, the study shows that real-time PCR could be used effectively for the quantification of cellular uptake of gene delivery vectors." @default.
- W2123319065 created "2016-06-24" @default.
- W2123319065 creator A5016187749 @default.
- W2123319065 creator A5024765200 @default.
- W2123319065 creator A5040446988 @default.
- W2123319065 creator A5081055239 @default.
- W2123319065 creator A5090599562 @default.
- W2123319065 date "2009-06-01" @default.
- W2123319065 modified "2023-09-24" @default.
- W2123319065 title "Cyclic RGD-targeting of reversibly stabilized DNA nanoparticles enhances cell uptake and transfection in vitro" @default.
- W2123319065 cites W141976550 @default.
- W2123319065 cites W1533504068 @default.
- W2123319065 cites W1576773659 @default.
- W2123319065 cites W187557848 @default.
- W2123319065 cites W1964704299 @default.
- W2123319065 cites W1965726357 @default.
- W2123319065 cites W1973123208 @default.
- W2123319065 cites W1973316675 @default.
- W2123319065 cites W1979206942 @default.
- W2123319065 cites W1999600810 @default.
- W2123319065 cites W2004678961 @default.
- W2123319065 cites W2006010807 @default.
- W2123319065 cites W2008000140 @default.
- W2123319065 cites W2013156289 @default.
- W2123319065 cites W2021797033 @default.
- W2123319065 cites W2025544291 @default.
- W2123319065 cites W2031630601 @default.
- W2123319065 cites W2054704112 @default.
- W2123319065 cites W2054877253 @default.
- W2123319065 cites W2059129915 @default.
- W2123319065 cites W2064800929 @default.
- W2123319065 cites W2071992333 @default.
- W2123319065 cites W2077090481 @default.
- W2123319065 cites W2078204057 @default.
- W2123319065 cites W2084955999 @default.
- W2123319065 cites W2085245921 @default.
- W2123319065 cites W2095414662 @default.
- W2123319065 cites W2099690168 @default.
- W2123319065 cites W2103431462 @default.
- W2123319065 cites W2118137379 @default.
- W2123319065 cites W2123717856 @default.
- W2123319065 cites W2125046292 @default.
- W2123319065 cites W2126630077 @default.
- W2123319065 cites W2132098166 @default.
- W2123319065 cites W2146820631 @default.
- W2123319065 cites W2147596158 @default.
- W2123319065 cites W2153173302 @default.
- W2123319065 cites W2154235560 @default.
- W2123319065 cites W2164271213 @default.
- W2123319065 cites W2321451097 @default.
- W2123319065 cites W2328920419 @default.
- W2123319065 cites W4242810598 @default.
- W2123319065 cites W4250893695 @default.
- W2123319065 doi "https://doi.org/10.1080/10611860902807046" @default.
- W2123319065 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4655816" @default.
- W2123319065 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19263264" @default.
- W2123319065 hasPublicationYear "2009" @default.
- W2123319065 type Work @default.
- W2123319065 sameAs 2123319065 @default.
- W2123319065 citedByCount "22" @default.
- W2123319065 countsByYear W21233190652012 @default.
- W2123319065 countsByYear W21233190652013 @default.
- W2123319065 countsByYear W21233190652014 @default.
- W2123319065 countsByYear W21233190652015 @default.
- W2123319065 countsByYear W21233190652018 @default.
- W2123319065 countsByYear W21233190652020 @default.
- W2123319065 countsByYear W21233190652021 @default.
- W2123319065 countsByYear W21233190652023 @default.
- W2123319065 crossrefType "journal-article" @default.
- W2123319065 hasAuthorship W2123319065A5016187749 @default.
- W2123319065 hasAuthorship W2123319065A5024765200 @default.
- W2123319065 hasAuthorship W2123319065A5040446988 @default.
- W2123319065 hasAuthorship W2123319065A5081055239 @default.
- W2123319065 hasAuthorship W2123319065A5090599562 @default.
- W2123319065 hasBestOaLocation W21233190652 @default.
- W2123319065 hasConcept C104317684 @default.
- W2123319065 hasConcept C111599444 @default.
- W2123319065 hasConcept C12554922 @default.
- W2123319065 hasConcept C135983454 @default.
- W2123319065 hasConcept C1491633281 @default.
- W2123319065 hasConcept C153911025 @default.
- W2123319065 hasConcept C15920480 @default.
- W2123319065 hasConcept C178790620 @default.
- W2123319065 hasConcept C185592680 @default.
- W2123319065 hasConcept C202751555 @default.
- W2123319065 hasConcept C2775961978 @default.
- W2123319065 hasConcept C2777411675 @default.
- W2123319065 hasConcept C2779402116 @default.
- W2123319065 hasConcept C502942594 @default.
- W2123319065 hasConcept C521977710 @default.
- W2123319065 hasConcept C54009773 @default.
- W2123319065 hasConcept C54355233 @default.
- W2123319065 hasConcept C552990157 @default.
- W2123319065 hasConcept C55493867 @default.
- W2123319065 hasConcept C81885089 @default.
- W2123319065 hasConcept C86803240 @default.
- W2123319065 hasConcept C95444343 @default.
- W2123319065 hasConceptScore W2123319065C104317684 @default.