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• W2123337166 abstract "Gastric inhibitory polypeptide (GIP) is an incretin released from enteroendocrine K cells in response to nutrient intake, especially fat. GIP is one of the contributing factors inducing fat accumulation that results in obesity. A recent study shows that fatty acid-binding protein 5 (FABP5) is expressed in murine K cells and is involved in fat-induced GIP secretion. We investigated the mechanism of fat-induced GIP secretion and the impact of FABP5-related GIP response on diet-induced obesity (DIO). Single oral administration of glucose and fat resulted in a 40% reduction of GIP response to fat but not to glucose in whole body FABP5-knockout (FABP5 −/− ) mice, with no change in K cell count or GIP content in K cells. In an ex vivo experiment using isolated upper small intestine, oleic acid induced only a slight increase in GIP release, which was markedly enhanced by coadministration of bile and oleic acid together with attenuated GIP response in the FABP5 −/− sample. FABP5 −/− mice exhibited a 24% reduction in body weight gain and body fat mass under a high-fat diet compared with wild-type (FABP5 +/+ ) mice; the difference was not observed between GIP-GFP homozygous knock-in (GIP gfp/gfp )-FABP5 +/+ mice and GIP gfp/gfp -FABP5 −/− mice, in which GIP is genetically deleted. These results demonstrate that bile efficiently amplifies fat-induced GIP secretion and that FABP5 contributes to the development of DIO in a GIP-dependent manner." @default.
• W2123337166 created "2016-06-24" @default.
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• W2123337166 date "2015-04-01" @default.
• W2123337166 modified "2023-10-14" @default.
• W2123337166 title "Fatty acid-binding protein 5 regulates diet-induced obesity via GIP secretion from enteroendocrine K cells in response to fat ingestion" @default.
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• W2123337166 doi "https://doi.org/10.1152/ajpendo.00543.2014" @default.
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