FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123340319> ?p ?o ?g. }

• W2123340319 endingPage "716" @default.
• W2123340319 startingPage "710" @default.
• W2123340319 abstract "Objective— 15-Deoxy-Δ 12,14 -prostaglandin J 2 (15d-PGJ2), a natural ligand of the peroxisome proliferator–activated receptor-γ (PPARγ), has been shown to inhibit proinflammatory gene expression, but the signaling mechanisms involved remain unclear. Because retinoic acid receptor–related orphan receptor-α (RORα) has been reported to suppress tumor necrosis factor-α (TNF-α)–induced expression of proinflammatory genes, we hypothesized that 15d-PGJ2 may induce RORα expression resulting in inhibition of proinflammatory gene expression. Methods and Results— We demonstrate that 15d-PGJ2 induced RORα1 and RORα4 expression and inhibited TNF-α–induced vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) expression in human umbilical vein endothelial cells (HUVECs). In contrast, the synthetic PPARγ ligand pioglitazone weakly induced RORα4 expression but did not affect RORα1 expression or TNF-α–induced gene expression. Biphenol A diglycidyl ether, a PPARγ antagonist, did not block the effect of 15d-PGJ2 on RORα expression. Adenovirus-mediated overexpression of RORα1 inhibited TNF-α–induced VCAM-1 and ICAM-1 expression, and overexpression of a mutant form of RORα1 (RORα1Δ), which inhibited transcriptional activity of RORα1 and RORα4, attenuated its inhibition. Furthermore, we found that RORα1Δ attenuated the inhibitory actions of 15d-PGJ2 on TNF-α–induced VCAM-1 and ICAM-1 expression. Conclusions— These results suggest that 15d-PGJ2 inhibits TNF-α–induced expression of proinflammatory genes mediated in part via induction of RORα in HUVECs. This mechanism provides a novel insight into PPARγ-independent actions of 15d-PGJ2." @default.
• W2123340319 created "2016-06-24" @default.
• W2123340319 creator A5018985536 @default.
• W2123340319 creator A5031161165 @default.
• W2123340319 date "2005-04-01" @default.
• W2123340319 modified "2023-09-25" @default.
• W2123340319 title "15-Deoxy-Δ12,14-Prostaglandin J2(15d-PGJ2) Signals Through Retinoic Acid Receptor–Related Orphan Receptor-α but Not Peroxisome Proliferator–Activated Receptor-γ in Human Vascular Endothelial Cells" @default.
• W2123340319 cites W1491042062 @default.
• W2123340319 cites W1539392991 @default.
• W2123340319 cites W1633340712 @default.
• W2123340319 cites W1639924204 @default.
• W2123340319 cites W1812573520 @default.
• W2123340319 cites W1969181250 @default.
• W2123340319 cites W1970474244 @default.
• W2123340319 cites W1982807310 @default.
• W2123340319 cites W1986543274 @default.
• W2123340319 cites W1989619519 @default.
• W2123340319 cites W1996267589 @default.
• W2123340319 cites W1999513011 @default.
• W2123340319 cites W2005674716 @default.
• W2123340319 cites W2015903618 @default.
• W2123340319 cites W2034522936 @default.
• W2123340319 cites W2039064135 @default.
• W2123340319 cites W2040565048 @default.
• W2123340319 cites W2043984428 @default.
• W2123340319 cites W2050717908 @default.
• W2123340319 cites W2051433588 @default.
• W2123340319 cites W2053242629 @default.
• W2123340319 cites W2059895383 @default.
• W2123340319 cites W2068820723 @default.
• W2123340319 cites W2073356061 @default.
• W2123340319 cites W2074011532 @default.
• W2123340319 cites W2079644509 @default.
• W2123340319 cites W2083217753 @default.
• W2123340319 cites W2099675490 @default.
• W2123340319 cites W2104224178 @default.
• W2123340319 cites W2109478329 @default.
• W2123340319 cites W2120936658 @default.
• W2123340319 cites W2133941138 @default.
• W2123340319 cites W2135565401 @default.
• W2123340319 cites W2167795186 @default.
• W2123340319 cites W2168509745 @default.
• W2123340319 cites W4230693812 @default.
• W2123340319 cites W4240789623 @default.
• W2123340319 cites W4247315158 @default.
• W2123340319 cites W4313344482 @default.
• W2123340319 cites W4362204104 @default.
• W2123340319 cites W62702228 @default.
• W2123340319 doi "https://doi.org/10.1161/01.atv.0000156482.76228.d1" @default.
• W2123340319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15662020" @default.
• W2123340319 hasPublicationYear "2005" @default.
• W2123340319 type Work @default.
• W2123340319 sameAs 2123340319 @default.
• W2123340319 citedByCount "15" @default.
• W2123340319 countsByYear W21233403192013 @default.
• W2123340319 countsByYear W21233403192015 @default.
• W2123340319 countsByYear W21233403192017 @default.
• W2123340319 countsByYear W21233403192021 @default.
• W2123340319 countsByYear W21233403192022 @default.
• W2123340319 crossrefType "journal-article" @default.
• W2123340319 hasAuthorship W2123340319A5018985536 @default.
• W2123340319 hasAuthorship W2123340319A5031161165 @default.
• W2123340319 hasBestOaLocation W21233403191 @default.
• W2123340319 hasConcept C104317684 @default.
• W2123340319 hasConcept C120197328 @default.
• W2123340319 hasConcept C164027704 @default.
• W2123340319 hasConcept C170493617 @default.
• W2123340319 hasConcept C185592680 @default.
• W2123340319 hasConcept C187345961 @default.
• W2123340319 hasConcept C203014093 @default.
• W2123340319 hasConcept C2776914184 @default.
• W2123340319 hasConcept C2779161069 @default.
• W2123340319 hasConcept C2781121885 @default.
• W2123340319 hasConcept C55493867 @default.
• W2123340319 hasConcept C63932345 @default.
• W2123340319 hasConcept C74737994 @default.
• W2123340319 hasConcept C86339819 @default.
• W2123340319 hasConcept C86803240 @default.
• W2123340319 hasConcept C89364313 @default.
• W2123340319 hasConcept C95444343 @default.
• W2123340319 hasConceptScore W2123340319C104317684 @default.
• W2123340319 hasConceptScore W2123340319C120197328 @default.
• W2123340319 hasConceptScore W2123340319C164027704 @default.
• W2123340319 hasConceptScore W2123340319C170493617 @default.
• W2123340319 hasConceptScore W2123340319C185592680 @default.
• W2123340319 hasConceptScore W2123340319C187345961 @default.
• W2123340319 hasConceptScore W2123340319C203014093 @default.
• W2123340319 hasConceptScore W2123340319C2776914184 @default.
• W2123340319 hasConceptScore W2123340319C2779161069 @default.
• W2123340319 hasConceptScore W2123340319C2781121885 @default.
• W2123340319 hasConceptScore W2123340319C55493867 @default.
• W2123340319 hasConceptScore W2123340319C63932345 @default.
• W2123340319 hasConceptScore W2123340319C74737994 @default.
• W2123340319 hasConceptScore W2123340319C86339819 @default.
• W2123340319 hasConceptScore W2123340319C86803240 @default.
• W2123340319 hasConceptScore W2123340319C89364313 @default.
• W2123340319 hasConceptScore W2123340319C95444343 @default.
• W2123340319 hasIssue "4" @default.

• next