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- W2123341306 endingPage "470" @default.
- W2123341306 startingPage "447" @default.
- W2123341306 abstract "Ezetimibe is a cholesterol absorption inhibitor that blocks the intestinal absorption of both biliary and dietary cholesterol. It appears to exert its effect by blocking intestinal sterol transporters, specifically Niemann-Pick C1-like 1 proteins, thereby inhibiting the intestinal absorption of cholesterol, phytosterols and certain oxysterols. Ezetimibe monotherapy and in combination with statin therapy is primarily indicated for lowering LDL-cholesterol levels. In addition, it may favorably affect other parameters that could potentially further reduce atherosclerotic coronary heart disease risk, such as raising HDL-cholesterol and lowering levels of triglycerides, non-HDL-cholesterol, apolipoprotein B and remnant-like particle cholesterol. Further effects of ezetimibe include a reduction in circulating phytosterols and oxysterols and, when used in combination with statins, a reduction in high-sensitivity C-reactive protein. The clinical significance of the LDL-cholesterol lowering and other effects of ezetimibe is being evaluated in clinical outcome studies." @default.
- W2123341306 created "2016-06-24" @default.
- W2123341306 creator A5040420889 @default.
- W2123341306 creator A5053191013 @default.
- W2123341306 creator A5066354341 @default.
- W2123341306 creator A5090460841 @default.
- W2123341306 date "2008-04-01" @default.
- W2123341306 modified "2023-10-11" @default.
- W2123341306 title "Ezetimibe: cholesterol lowering and beyond" @default.
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