Matches in SemOpenAlex for { <https://semopenalex.org/work/W212335784> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W212335784 endingPage "93" @default.
- W212335784 startingPage "1787" @default.
- W212335784 abstract "We investigated whether the levels of the DNA-dependent protein kinase (DNA-PK) activity and content correlate with drug sensitivity in different tumour materials and if this can be utilised in predicting treatment outcome. DNA-PK activity and expression were investigated in tumour cells from 8 patients with chronic lymphocytic leukaemia (CLL) and 18 patients with acute myeloid leukaemia (AML), using Western blot and DNA-PK kinase activity assay. Tumour cells from the patients were investigated for their drug sensitivity to topoisomerase II inhibitors (doxorubicin and etoposide), DNA reactive agents (melphalan, 4-hydroxycyclophosphamide and cisplatinum), an antimetabolite (cytosine arabinoside) and an antimicrotubule agent (vincristine) by fluorometric microculture cytotoxicity assay (FMCA). Within each group of leukaemia there was a large variation in both DNA-PK activity and DNA-PKcs expression, while the Ku subunits were expressed more homogeneously. In CLL cells, sensitivity to topoisomerase II inhibitors correlated with DNA-PKcs protein expression (r=0.7174, p=0.0452). In AML samples, sensitivity to DNA cross-linking alkylating agents correlated with Ku86 (r=-0.7512, p=0.0031) and Ku70 (r=-0.6134, p=0.0258) expression. Unexpectedly, DNA-PK activity was found to correlate with sensitivity to vincristine in both CLL (r=0.8557, p=0.0067) and AML (r=0.5480, p=0.0228) cells. The results indicate that DNA-PK is not only involved in the recognition of DNA double-strand breaks (DSB), but also other DNA lesions." @default.
- W212335784 created "2016-06-24" @default.
- W212335784 creator A5028160249 @default.
- W212335784 creator A5033569106 @default.
- W212335784 creator A5066611490 @default.
- W212335784 creator A5087206674 @default.
- W212335784 date "2002-08-10" @default.
- W212335784 modified "2023-09-23" @default.
- W212335784 title "DNA-dependent protein kinase in leukaemia cells and correlation with drug sensitivity." @default.
- W212335784 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12168870" @default.
- W212335784 hasPublicationYear "2002" @default.
- W212335784 type Work @default.
- W212335784 sameAs 212335784 @default.
- W212335784 citedByCount "12" @default.
- W212335784 countsByYear W2123357842012 @default.
- W212335784 countsByYear W2123357842016 @default.
- W212335784 countsByYear W2123357842017 @default.
- W212335784 countsByYear W2123357842019 @default.
- W212335784 crossrefType "journal-article" @default.
- W212335784 hasAuthorship W212335784A5028160249 @default.
- W212335784 hasAuthorship W212335784A5033569106 @default.
- W212335784 hasAuthorship W212335784A5066611490 @default.
- W212335784 hasAuthorship W212335784A5087206674 @default.
- W212335784 hasConcept C147897179 @default.
- W212335784 hasConcept C153911025 @default.
- W212335784 hasConcept C2776694085 @default.
- W212335784 hasConcept C2776755627 @default.
- W212335784 hasConcept C2778041864 @default.
- W212335784 hasConcept C2778119113 @default.
- W212335784 hasConcept C2778684742 @default.
- W212335784 hasConcept C2778729363 @default.
- W212335784 hasConcept C2779429289 @default.
- W212335784 hasConcept C2780147359 @default.
- W212335784 hasConcept C502942594 @default.
- W212335784 hasConcept C54355233 @default.
- W212335784 hasConcept C552990157 @default.
- W212335784 hasConcept C55493867 @default.
- W212335784 hasConcept C86803240 @default.
- W212335784 hasConceptScore W212335784C147897179 @default.
- W212335784 hasConceptScore W212335784C153911025 @default.
- W212335784 hasConceptScore W212335784C2776694085 @default.
- W212335784 hasConceptScore W212335784C2776755627 @default.
- W212335784 hasConceptScore W212335784C2778041864 @default.
- W212335784 hasConceptScore W212335784C2778119113 @default.
- W212335784 hasConceptScore W212335784C2778684742 @default.
- W212335784 hasConceptScore W212335784C2778729363 @default.
- W212335784 hasConceptScore W212335784C2779429289 @default.
- W212335784 hasConceptScore W212335784C2780147359 @default.
- W212335784 hasConceptScore W212335784C502942594 @default.
- W212335784 hasConceptScore W212335784C54355233 @default.
- W212335784 hasConceptScore W212335784C552990157 @default.
- W212335784 hasConceptScore W212335784C55493867 @default.
- W212335784 hasConceptScore W212335784C86803240 @default.
- W212335784 hasIssue "3" @default.
- W212335784 hasLocation W2123357841 @default.
- W212335784 hasOpenAccess W212335784 @default.
- W212335784 hasPrimaryLocation W2123357841 @default.
- W212335784 hasRelatedWork W1970413813 @default.
- W212335784 hasRelatedWork W2015320100 @default.
- W212335784 hasRelatedWork W2061029651 @default.
- W212335784 hasRelatedWork W212335784 @default.
- W212335784 hasRelatedWork W2162389158 @default.
- W212335784 hasRelatedWork W2166157350 @default.
- W212335784 hasRelatedWork W2353584562 @default.
- W212335784 hasRelatedWork W2471656433 @default.
- W212335784 hasRelatedWork W2529807818 @default.
- W212335784 hasRelatedWork W2548152753 @default.
- W212335784 hasVolume "22" @default.
- W212335784 isParatext "false" @default.
- W212335784 isRetracted "false" @default.
- W212335784 magId "212335784" @default.
- W212335784 workType "article" @default.