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- W2123392987 abstract "To determine whether the functional effects of oral supplementation with Saffron, a natural compound that proved to be neuroprotective in early age-related macular degeneration, are influenced by complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2) risk genotypes. Thirty-three early AMD patients, screened for CFH (rs1061170) and ARMS2 (rs10490924) polymorphisms and receiving Saffron oral supplementation (20 mg/day) over an average period of treatment of 11 months (range, 6–12), were longitudinally evaluated by clinical examination and focal electroretinogram (fERG)-derived macular (18°) flicker sensitivity estimate. fERG amplitude and macular sensitivity, the reciprocal value of the estimated fERG amplitude threshold, were the main outcome measures. After three months of supplementation, mean fERG amplitude and fERG sensitivity improved significantly when compared to baseline values (p < 0.01). These changes were stable throughout the follow-up period. No significant differences in clinical and fERG improvements were observed across different CFH or ARMS2 genotypes. The present results indicate that the functional effect of Saffron supplementation in individual AMD patients is not related to the major risk genotypes of disease." @default.
- W2123392987 created "2016-06-24" @default.
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- W2123392987 date "2013-01-01" @default.
- W2123392987 modified "2023-10-03" @default.
- W2123392987 title "Functional effect of Saffron supplementation and risk genotypes in early age-related macular degeneration: a preliminary report" @default.
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- W2123392987 doi "https://doi.org/10.1186/1479-5876-11-228" @default.
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