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• W2123399324 abstract "Aims: Tumour necrosis factor (TNF)‐α induces death or cell proliferation by activation of nuclear factor (NF)‐κB, also activated by interleukin (IL)‐1α. The aim was to investigate upstream and downstream components of NIK transduction pathway in normal (NP), benign prostatic hyperplasia (BPH), prostatic intraepithelial neoplasia (PIN) and prostatic carcinoma (PC). Methods and results: Immunohistochemistry and Western blotting were performed. In NP, the cytoplasm of epithelial cells was intensely immunoreactive to IL‐1 receptor‐associated kinase (IRAK), TNF receptor‐associated factor (TRAF)‐6, NF‐κB inducing kinase (NIK), Iκκα/β, IκBα and p‐IκB; weakly to NF‐κB‐p50; and negative to NF‐κB‐p65. BPH samples were intensely immunoreactive to IRAK, TRAF‐6, NIK, Iκκα/β, IκBα, p‐IκB; weakly to NF‐κB‐p50 and NF‐κB‐p65. Whereas low‐grade PIN showed intermediate results between NP and BPH, results in high‐grade PIN were similar to those found in PC (low Gleason). In PC, immunoreactivity was intense for IRAK, TRAF‐6, NIK, Iκκα/β (increasing with Gleason), IκBα, p‐IκB (decreasing with Gleason); weak for NF‐κB‐p50 and NF‐κB‐p65 (decreasing with Gleason). Nuclear NF‐κB was observed in PC. Conclusions: NF‐κB enhances cell proliferation, but also ATF‐2 or Elk‐1. Since IL‐1 and TNF‐α are related to inflammation and their immunoexpression increases in PC, inhibition of these cytokines might be a possible target for PC treatment, because they decrease the activity of all transduction pathway members that activate transcription factors such as NF‐κB, Elk‐1 or ATF‐2." @default.
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• W2123399324 date "2008-07-22" @default.
• W2123399324 modified "2023-10-16" @default.
• W2123399324 title "TNF/IL-1/NIK/NF-κB transduction pathway: a comparative study in normal and pathological human prostate (benign hyperplasia and carcinoma)" @default.
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• W2123399324 doi "https://doi.org/10.1111/j.1365-2559.2008.03092.x" @default.
• W2123399324 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18752500" @default.
• W2123399324 hasPublicationYear "2008" @default.
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