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- W2123402012 abstract "Ghrelin is a stomach hormone that acts as an endogenous ligand of orphan G-protein-coupled receptor. Ghrelin is a 28-amino acid peptide existing in two major forms: n-octanoyl-modified ghrelin, which possesses an n-octanoyl modification on serine-3 and des-acyl ghrelin. Fatty acid modification of ghrelin is essential for ghrelin-induced growth hormone release from the pituitary and appetite stimulation. This acyl-modification of ghrelin is catalysed by ghrelin-O-acyl transferase recently identified. Despite the number of innovative advancements in this field of research, there are still many aspects of ghrelin function and biosynthesis process that remain to be clarified. Here, we review the current understanding of the structure, regulation and function of ghrelin; this review is intended for researchers who will be involved in this field in the future." @default.
- W2123402012 created "2016-06-24" @default.
- W2123402012 creator A5006844282 @default.
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- W2123402012 creator A5064467364 @default.
- W2123402012 creator A5068354355 @default.
- W2123402012 creator A5080822459 @default.
- W2123402012 date "2011-10-31" @default.
- W2123402012 modified "2023-10-17" @default.
- W2123402012 title "Structure, regulation and function of ghrelin" @default.
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