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- W2123405128 abstract "One of the pathophysiological features of Alzheimer's disease is astrocytosis around senile plaques. Reactive astrocytes may produce proinflammatory mediators, nitric oxide, and subsequent reactive oxygen intermediates such as peroxynitrites. In the present study, we investigated the possible role of the C-terminal fragment of amyloid precursor protein (CT-APP), which is another constituent of amyloid senile plaque and an abnormal product of APP metabolism, as an inducer of astrocytosis. We report that 100 nm recombinant C-terminal 105 amino acid fragment (CT105) of APP induced astrocytosis morphologically and immunologically. CT105 exposure resulted in activation of mitogen-activated protein kinase (MAPK) pathways as well as transcription factor NF-κB. Pretreatment with PD098059 and/or SB203580 decreased nitric oxide (NO) production and nuclear factor-kappa B (NF-κB) activation. But inhibitors of NF-κB activation did not affect MAPKs activation whereas they abolished NO production and attenuated astrocytosis. Furthermore, conditioned media derived from CT105-treated astrocytes enhanced neurotoxicity and pretreatment with NO and peroxynitrite scavengers attenuated its toxicity. These suggest that CT-APP may participate in Alzheimer's pathogenesis through MAPKs- and NF-κB-dependent astrocytosis and iNOS induction." @default.
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- W2123405128 date "2001-12-20" @default.
- W2123405128 modified "2023-09-23" @default.
- W2123405128 title "C-terminal fragment of amyloid precursor protein induces astrocytosis" @default.
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- W2123405128 cites W1662308449 @default.
- W2123405128 cites W1821918060 @default.
- W2123405128 cites W1965742689 @default.
- W2123405128 cites W1966984711 @default.
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- W2123405128 cites W1972034064 @default.
- W2123405128 cites W1974747340 @default.
- W2123405128 cites W1976989696 @default.
- W2123405128 cites W1983601412 @default.
- W2123405128 cites W1983955783 @default.
- W2123405128 cites W1987588502 @default.
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- W2123405128 cites W1990802251 @default.
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- W2123405128 cites W1991763618 @default.
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- W2123405128 cites W2034354351 @default.
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- W2123405128 doi "https://doi.org/10.1046/j.1471-4159.2001.00370.x" @default.
- W2123405128 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11432978" @default.
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