FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123417307> ?p ?o ?g. }

• W2123417307 endingPage "32" @default.
• W2123417307 startingPage "125" @default.
• W2123417307 abstract "Herbal medical compounds and their major constituent have been used in the management and treatment of opioid withdrawal syndrome and pain. This study was carried out to clarify the effect of curcumin, the major compound of turmeric, on morphine withdrawal syndrome in mouse model and its possible mechanisms of pain relieving activity by assessing in writhing test as a model of visceral pain.Due to two separate protocols (withdrawal syndrome and pain), 144 male albino mice were divided in two major groups. In withdrawal syndrome group, test effect of various dosages of curcumin (10, 20, and 40 mg/kg) was assessed on withdrawal signs and compared with positive and negative control and standard treatment (clonidine 0.4 mg/kg) groups. In pain groups, to determine the mechanism of pain relieving activity of curcumin, various dosages of curcumin (10, 20, and 40 mg/kg) in three separated groups, were used against acetic acid induced writhing (which is a constriction) test. The most effective dose (40 mg/kg) was used in writhing test and compared with groups pretreated with antagonist of major neurotransmitters involved in pain; and compared with group pretreated with vehicle (DMSO, 0.05%) as control.Curcumin attenuates withdrawal syndrome in a dose dependent manner in comparison with the dependent positive control group (P<0.05). It also indicated that pretreatment with naloxone and cyproheptadine significantly attenuate antinociception effect of curcumin (P<0.05).This study advocate that antinociception of curcumin was mediated by opioidergic and adrenergic system." @default.
• W2123417307 created "2016-06-24" @default.
• W2123417307 creator A5004082010 @default.
• W2123417307 creator A5010912537 @default.
• W2123417307 creator A5018212455 @default.
• W2123417307 creator A5026405226 @default.
• W2123417307 creator A5073096181 @default.
• W2123417307 date "2015-03-01" @default.
• W2123417307 modified "2023-09-29" @default.
• W2123417307 title "Attenuation of morphine withdrawal syndrome by various dosages of curcumin in comparison with clonidine in mouse: possible mechanism." @default.
• W2123417307 cites W1586405889 @default.
• W2123417307 cites W1966202096 @default.
• W2123417307 cites W197696580 @default.
• W2123417307 cites W1977290655 @default.
• W2123417307 cites W1980474344 @default.
• W2123417307 cites W1986498366 @default.
• W2123417307 cites W1991605631 @default.
• W2123417307 cites W1992795501 @default.
• W2123417307 cites W1993519646 @default.
• W2123417307 cites W2000863302 @default.
• W2123417307 cites W2003798699 @default.
• W2123417307 cites W2008107953 @default.
• W2123417307 cites W2025703815 @default.
• W2123417307 cites W2034027188 @default.
• W2123417307 cites W2034446429 @default.
• W2123417307 cites W2036062643 @default.
• W2123417307 cites W2055293999 @default.
• W2123417307 cites W2060662813 @default.
• W2123417307 cites W2061723277 @default.
• W2123417307 cites W2070728496 @default.
• W2123417307 cites W2080996905 @default.
• W2123417307 cites W2084111066 @default.
• W2123417307 cites W2094381755 @default.
• W2123417307 cites W2108978934 @default.
• W2123417307 cites W2111629505 @default.
• W2123417307 cites W2117864279 @default.
• W2123417307 cites W2118087188 @default.
• W2123417307 cites W2142999617 @default.
• W2123417307 cites W2150458222 @default.
• W2123417307 cites W572547045 @default.
• W2123417307 cites W1497278314 @default.
• W2123417307 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4359932" @default.
• W2123417307 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25821292" @default.
• W2123417307 hasPublicationYear "2015" @default.
• W2123417307 type Work @default.
• W2123417307 sameAs 2123417307 @default.
• W2123417307 citedByCount "9" @default.
• W2123417307 countsByYear W21234173072015 @default.
• W2123417307 countsByYear W21234173072016 @default.
• W2123417307 countsByYear W21234173072017 @default.
• W2123417307 countsByYear W21234173072019 @default.
• W2123417307 countsByYear W21234173072020 @default.
• W2123417307 countsByYear W21234173072021 @default.
• W2123417307 countsByYear W21234173072022 @default.
• W2123417307 crossrefType "journal-article" @default.
• W2123417307 hasAuthorship W2123417307A5004082010 @default.
• W2123417307 hasAuthorship W2123417307A5010912537 @default.
• W2123417307 hasAuthorship W2123417307A5018212455 @default.
• W2123417307 hasAuthorship W2123417307A5026405226 @default.
• W2123417307 hasAuthorship W2123417307A5073096181 @default.
• W2123417307 hasConcept C126322002 @default.
• W2123417307 hasConcept C162156334 @default.
• W2123417307 hasConcept C170493617 @default.
• W2123417307 hasConcept C2777389121 @default.
• W2123417307 hasConcept C2778250585 @default.
• W2123417307 hasConcept C2778399450 @default.
• W2123417307 hasConcept C2778750930 @default.
• W2123417307 hasConcept C2779004600 @default.
• W2123417307 hasConcept C2780820201 @default.
• W2123417307 hasConcept C2781063702 @default.
• W2123417307 hasConcept C42219234 @default.
• W2123417307 hasConcept C71924100 @default.
• W2123417307 hasConcept C98274493 @default.
• W2123417307 hasConceptScore W2123417307C126322002 @default.
• W2123417307 hasConceptScore W2123417307C162156334 @default.
• W2123417307 hasConceptScore W2123417307C170493617 @default.
• W2123417307 hasConceptScore W2123417307C2777389121 @default.
• W2123417307 hasConceptScore W2123417307C2778250585 @default.
• W2123417307 hasConceptScore W2123417307C2778399450 @default.
• W2123417307 hasConceptScore W2123417307C2778750930 @default.
• W2123417307 hasConceptScore W2123417307C2779004600 @default.
• W2123417307 hasConceptScore W2123417307C2780820201 @default.
• W2123417307 hasConceptScore W2123417307C2781063702 @default.
• W2123417307 hasConceptScore W2123417307C42219234 @default.
• W2123417307 hasConceptScore W2123417307C71924100 @default.
• W2123417307 hasConceptScore W2123417307C98274493 @default.
• W2123417307 hasIssue "2" @default.
• W2123417307 hasLocation W21234173071 @default.
• W2123417307 hasOpenAccess W2123417307 @default.
• W2123417307 hasPrimaryLocation W21234173071 @default.
• W2123417307 hasRelatedWork W1780106503 @default.
• W2123417307 hasRelatedWork W1971792289 @default.
• W2123417307 hasRelatedWork W1979335616 @default.
• W2123417307 hasRelatedWork W2007798656 @default.
• W2123417307 hasRelatedWork W2029653100 @default.
• W2123417307 hasRelatedWork W2056888952 @default.
• W2123417307 hasRelatedWork W2064711371 @default.
• W2123417307 hasRelatedWork W2097635080 @default.

• next