Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123418464> ?p ?o ?g. }
- W2123418464 endingPage "320" @default.
- W2123418464 startingPage "309" @default.
- W2123418464 abstract "The conserved MIA pathway is responsible for the import and oxidative folding of proteins destined for the intermembrane space of mitochondria. In contrast to a wealth of information obtained from studies with yeast, the function of the MIA pathway in higher eukaryotes has remained enigmatic. Here, we took advantage of the molecular understanding of the MIA pathway in yeast and designed a model of the human MIA pathway. The yeast model for MIA consists of two critical components, the disulfide bond carrier Mia40 and sulfhydryl oxidase Erv1/ALR. Human MIA40 and ALR substituted for their yeast counterparts in the essential function for the oxidative biogenesis of mitochondrial intermembrane space proteins. In addition, the sulfhydryl oxidases ALR/Erv1 were found to be involved in the mitochondrial localization of human MIA40. Furthermore, the defective accumulation of human MIA40 in mitochondria underlies a recently identified disease that is caused by amino acid exchange in ALR. Thus, human ALR is an important factor that controls not only the ability of MIA40 to bind and oxidize protein clients but also the localization of human MIA40 in mitochondria." @default.
- W2123418464 created "2016-06-24" @default.
- W2123418464 creator A5051624397 @default.
- W2123418464 creator A5060732054 @default.
- W2123418464 creator A5081396858 @default.
- W2123418464 creator A5088678472 @default.
- W2123418464 date "2012-12-16" @default.
- W2123418464 modified "2023-10-18" @default.
- W2123418464 title "Disulfide Bond Formation: Sulfhydryl Oxidase ALR Controls Mitochondrial Biogenesis of Human MIA40" @default.
- W2123418464 cites W1673046203 @default.
- W2123418464 cites W1972934808 @default.
- W2123418464 cites W1973788927 @default.
- W2123418464 cites W1974363114 @default.
- W2123418464 cites W1975384954 @default.
- W2123418464 cites W1975612270 @default.
- W2123418464 cites W1979484538 @default.
- W2123418464 cites W1982766793 @default.
- W2123418464 cites W1985609571 @default.
- W2123418464 cites W1986514138 @default.
- W2123418464 cites W1986542874 @default.
- W2123418464 cites W1991219316 @default.
- W2123418464 cites W1991485583 @default.
- W2123418464 cites W1992989338 @default.
- W2123418464 cites W1994507245 @default.
- W2123418464 cites W1994713290 @default.
- W2123418464 cites W1995281919 @default.
- W2123418464 cites W2002364392 @default.
- W2123418464 cites W2016121977 @default.
- W2123418464 cites W2016717346 @default.
- W2123418464 cites W2016980705 @default.
- W2123418464 cites W2019250081 @default.
- W2123418464 cites W2029471191 @default.
- W2123418464 cites W2036794157 @default.
- W2123418464 cites W2038770351 @default.
- W2123418464 cites W2042774137 @default.
- W2123418464 cites W2052595824 @default.
- W2123418464 cites W2056099910 @default.
- W2123418464 cites W2057576135 @default.
- W2123418464 cites W2062167511 @default.
- W2123418464 cites W2066009906 @default.
- W2123418464 cites W2069021425 @default.
- W2123418464 cites W2070622658 @default.
- W2123418464 cites W2076363488 @default.
- W2123418464 cites W2079498308 @default.
- W2123418464 cites W2088238130 @default.
- W2123418464 cites W2092460504 @default.
- W2123418464 cites W2092899472 @default.
- W2123418464 cites W2098842133 @default.
- W2123418464 cites W2102761129 @default.
- W2123418464 cites W2105954402 @default.
- W2123418464 cites W2107058904 @default.
- W2123418464 cites W2108254434 @default.
- W2123418464 cites W2110651189 @default.
- W2123418464 cites W2114341896 @default.
- W2123418464 cites W2122865359 @default.
- W2123418464 cites W2126995384 @default.
- W2123418464 cites W2128735996 @default.
- W2123418464 cites W2129055445 @default.
- W2123418464 cites W2129232617 @default.
- W2123418464 cites W2131415852 @default.
- W2123418464 cites W2134962337 @default.
- W2123418464 cites W2137515343 @default.
- W2123418464 cites W2143990004 @default.
- W2123418464 cites W2144458008 @default.
- W2123418464 cites W2146355213 @default.
- W2123418464 cites W2146850162 @default.
- W2123418464 cites W2150164439 @default.
- W2123418464 cites W2158635954 @default.
- W2123418464 cites W2162526561 @default.
- W2123418464 cites W2164228620 @default.
- W2123418464 cites W2164377269 @default.
- W2123418464 cites W2169333620 @default.
- W2123418464 doi "https://doi.org/10.1111/tra.12030" @default.
- W2123418464 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23186364" @default.
- W2123418464 hasPublicationYear "2012" @default.
- W2123418464 type Work @default.
- W2123418464 sameAs 2123418464 @default.
- W2123418464 citedByCount "44" @default.
- W2123418464 countsByYear W21234184642013 @default.
- W2123418464 countsByYear W21234184642014 @default.
- W2123418464 countsByYear W21234184642015 @default.
- W2123418464 countsByYear W21234184642016 @default.
- W2123418464 countsByYear W21234184642017 @default.
- W2123418464 countsByYear W21234184642018 @default.
- W2123418464 countsByYear W21234184642019 @default.
- W2123418464 countsByYear W21234184642020 @default.
- W2123418464 countsByYear W21234184642021 @default.
- W2123418464 countsByYear W21234184642022 @default.
- W2123418464 crossrefType "journal-article" @default.
- W2123418464 hasAuthorship W2123418464A5051624397 @default.
- W2123418464 hasAuthorship W2123418464A5060732054 @default.
- W2123418464 hasAuthorship W2123418464A5081396858 @default.
- W2123418464 hasAuthorship W2123418464A5088678472 @default.
- W2123418464 hasConcept C104317684 @default.
- W2123418464 hasConcept C131934819 @default.
- W2123418464 hasConcept C146587185 @default.
- W2123418464 hasConcept C158617107 @default.
- W2123418464 hasConcept C186850619 @default.