FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123448214> ?p ?o ?g. }

• W2123448214 endingPage "2137" @default.
• W2123448214 startingPage "2130" @default.
• W2123448214 abstract "LIGHT is a member of the tumor necrosis factor (TNF) superfamily, and its function is mediated by at least two receptors, including lymphotoxin beta receptor (LTbetaR) and herpes simplex virus entry mediator. However, the molecular mechanism of LIGHT signaling mediated by LTbetaR has not been clearly defined. In this report, we demonstrate that TRAF2 is critical for LIGHT- and LTbetaR-mediated activation of both the transcription factor NF-kappaB and the mitogen-activated protein kinase JNK. In HeLa cells, LIGHT induces NF-kappaB and JNK activation, which can be blocked by the dominant negative mutant of TRAF2. In these cells, LIGHT causes the recruitment of TRAF2, TRAF3, and IkappaB kinase into the LTbetaR complex. Importantly, while both NF-kappaB and JNK are activated by LIGHT in wild-type mouse embryonic fibroblasts, no activation of either of these two pathways is observed in TRAF2 null fibroblasts. However, LIGHT-induced NF-kappaB and JNK activation can be restored by ectopic expression of TRAF2 in TRAF2-/- cells. Interestingly, in contrast to TNF signaling, the activation of both NF-kappaB and JNK by LIGHT was normal in RIP-/- and TRAF5-/- cells. Taken together, our data demonstrate that TRAF2, an important effector molecule of TNF signaling, plays a critical, nonredundant role in LIGHT-LTbetaR signaling." @default.
• W2123448214 created "2016-06-24" @default.
• W2123448214 creator A5013001925 @default.
• W2123448214 creator A5017327882 @default.
• W2123448214 creator A5068691968 @default.
• W2123448214 date "2005-03-01" @default.
• W2123448214 modified "2023-10-01" @default.
• W2123448214 title "TRAF2 Plays a Key, Nonredundant Role in LIGHT-Lymphotoxin β Receptor Signaling" @default.
• W2123448214 cites W1506071020 @default.
• W2123448214 cites W1585759889 @default.
• W2123448214 cites W1620571444 @default.
• W2123448214 cites W166844354 @default.
• W2123448214 cites W1870863388 @default.
• W2123448214 cites W1963761369 @default.
• W2123448214 cites W1970514185 @default.
• W2123448214 cites W1972195950 @default.
• W2123448214 cites W1972366604 @default.
• W2123448214 cites W1978498711 @default.
• W2123448214 cites W1979595147 @default.
• W2123448214 cites W1987531976 @default.
• W2123448214 cites W1993731501 @default.
• W2123448214 cites W2001651353 @default.
• W2123448214 cites W2014373584 @default.
• W2123448214 cites W2021688965 @default.
• W2123448214 cites W2023653272 @default.
• W2123448214 cites W2025609599 @default.
• W2123448214 cites W2039478887 @default.
• W2123448214 cites W2041170922 @default.
• W2123448214 cites W2046265685 @default.
• W2123448214 cites W2046553655 @default.
• W2123448214 cites W2046927378 @default.
• W2123448214 cites W2064537387 @default.
• W2123448214 cites W2065257477 @default.
• W2123448214 cites W2072380594 @default.
• W2123448214 cites W2074150439 @default.
• W2123448214 cites W2076515532 @default.
• W2123448214 cites W2078960019 @default.
• W2123448214 cites W2086860754 @default.
• W2123448214 cites W2090369370 @default.
• W2123448214 cites W2093030407 @default.
• W2123448214 cites W2103944436 @default.
• W2123448214 cites W2105514243 @default.
• W2123448214 cites W2106877484 @default.
• W2123448214 cites W2107411016 @default.
• W2123448214 cites W2109044040 @default.
• W2123448214 cites W2113765407 @default.
• W2123448214 cites W2116063836 @default.
• W2123448214 cites W2117173182 @default.
• W2123448214 cites W2117327528 @default.
• W2123448214 cites W2119503603 @default.
• W2123448214 cites W2124202816 @default.
• W2123448214 cites W2129668511 @default.
• W2123448214 cites W2135627750 @default.
• W2123448214 cites W2138004606 @default.
• W2123448214 cites W2140450674 @default.
• W2123448214 cites W2140662490 @default.
• W2123448214 cites W2142541950 @default.
• W2123448214 cites W2143937186 @default.
• W2123448214 cites W2147286656 @default.
• W2123448214 cites W2147507133 @default.
• W2123448214 cites W2147921405 @default.
• W2123448214 cites W2158969445 @default.
• W2123448214 cites W2171525876 @default.
• W2123448214 cites W2470223656 @default.
• W2123448214 cites W4242818520 @default.
• W2123448214 doi "https://doi.org/10.1128/mcb.25.6.2130-2137.2005" @default.
• W2123448214 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1061604" @default.
• W2123448214 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15743811" @default.
• W2123448214 hasPublicationYear "2005" @default.
• W2123448214 type Work @default.
• W2123448214 sameAs 2123448214 @default.
• W2123448214 citedByCount "47" @default.
• W2123448214 countsByYear W21234482142012 @default.
• W2123448214 countsByYear W21234482142013 @default.
• W2123448214 countsByYear W21234482142014 @default.
• W2123448214 countsByYear W21234482142015 @default.
• W2123448214 countsByYear W21234482142016 @default.
• W2123448214 countsByYear W21234482142018 @default.
• W2123448214 countsByYear W21234482142020 @default.
• W2123448214 countsByYear W21234482142021 @default.
• W2123448214 countsByYear W21234482142022 @default.
• W2123448214 crossrefType "journal-article" @default.
• W2123448214 hasAuthorship W2123448214A5013001925 @default.
• W2123448214 hasAuthorship W2123448214A5017327882 @default.
• W2123448214 hasAuthorship W2123448214A5068691968 @default.
• W2123448214 hasBestOaLocation W21234482141 @default.
• W2123448214 hasConcept C103813035 @default.
• W2123448214 hasConcept C104317684 @default.
• W2123448214 hasConcept C123233396 @default.
• W2123448214 hasConcept C123298856 @default.
• W2123448214 hasConcept C153911025 @default.
• W2123448214 hasConcept C17991360 @default.
• W2123448214 hasConcept C190283241 @default.
• W2123448214 hasConcept C203014093 @default.
• W2123448214 hasConcept C2776472363 @default.
• W2123448214 hasConcept C2779004061 @default.
• W2123448214 hasConcept C31573885 @default.
• W2123448214 hasConcept C502942594 @default.

• next