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- W2123451825 endingPage "169" @default.
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- W2123451825 abstract "Cyclosporine A is an efficient immunosuppressive agent, however, its use is associated with complex alterations of vascular tone. Numerous clinical and experimental observations indicate acute and chronic effects of cyclosporine A that are modulating endothelial and vascular smooth muscle function. Cyclosporine A impairs the vasodilator function of the endothelium; at the vascular smooth muscle contractions to angiotensin II are augmented, whereas conflicting results were obtained with other vasoconstrictors. Furthermore, cyclosporine A may alter circulating and locally released vasoactive hormons, such as renin/angiotensin II, catecholamines and endothelin-1. The cellular mechanisms mediating the effects of cyclosporine A in the arterial wall are not completely understood, but several experimental findings give a more and more detailed picture of potentially involved systems." @default.
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- W2123451825 date "1996-01-01" @default.
- W2123451825 modified "2023-09-26" @default.
- W2123451825 title "Regulation of Vascular Tone during Treatment with Cyclosporine A: Modulation of Endothelial and Vascular Smooth Muscle Function" @default.
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- W2123451825 doi "https://doi.org/10.3109/10623329609024692" @default.
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