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• W2123451837 abstract "A series of novel S-DABO derivatives with the substituted 1,2,3-triazole moiety on the C-2 side chain were synthesized using the simple and efficient CuAAC reaction, and biologically evaluated as inhibitors of HIV-1. Among them, the most active HIV-1 inhibitor was compound 4-((4-((4-(2,6-dichlorobenzyl)-5-methyl-6-oxo-1,6-dihydropyrimidin-2-ylthio)methyl)-1H-1,2,3-triazol-1-yl)methyl)benzenesulfonamide (B5b7), which exhibited similar HIV-1 inhibitory potency (EC50 = 3.22 μm) compared with 3TC (EC50 = 2.24 μm). None of these compounds demonstrated inhibition against HIV-2 replication. The preliminary structure-activity relationship (SAR) of these new derivatives was discussed briefly." @default.
• W2123451837 created "2016-06-24" @default.
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• W2123451837 date "2015-02-19" @default.
• W2123451837 modified "2023-10-14" @default.
• W2123451837 title "Synthesis and Biological Evaluation of a Series of 2-((1-substituted-1<i>H</i>-1,2,3-triazol-4-yl)methylthio)-6-(naphthalen-1-ylmethyl)pyrimidin-4(3<i>H</i>)-one As Potential HIV-1 Inhibitors" @default.
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• W2123451837 doi "https://doi.org/10.1111/cbdd.12524" @default.
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