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- W2123453078 abstract "Abstract Skeletal muscle has a pleiotropic role in organismal energy metabolism, for example, by storing protein as an energy source, or by excreting endocrine hormones. Muscle proteolysis is tightly controlled by the hypothalamus-pituitary-adrenal signalling axis via a glucocorticoid-driven transcriptional programme. Here we unravel the physiological significance of this catabolic process using skeletal muscle-specific glucocorticoid receptor ( GR ) knockout (GRmKO) mice. These mice have increased muscle mass but smaller adipose tissues. Metabolically, GRmKO mice show a drastic shift of energy utilization and storage in muscle, liver and adipose tissues. We demonstrate that the resulting depletion of plasma alanine serves as a cue to increase plasma levels of fibroblast growth factor 21 (FGF21) and activates liver-fat communication, leading to the activation of lipolytic genes in adipose tissues. We propose that this skeletal muscle-liver-fat signalling axis may serve as a target for the development of therapies against various metabolic diseases, including obesity." @default.
- W2123453078 created "2016-06-24" @default.
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- W2123453078 date "2015-04-01" @default.
- W2123453078 modified "2023-10-15" @default.
- W2123453078 title "A muscle-liver-fat signalling axis is essential for central control of adaptive adipose remodelling" @default.
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- W2123453078 doi "https://doi.org/10.1038/ncomms7693" @default.
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