FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123455592> ?p ?o ?g. }

• W2123455592 endingPage "1689" @default.
• W2123455592 startingPage "1683" @default.
• W2123455592 abstract "Despite the widespread use of the Mycobacterium bovis BCG vaccine, there are more than 9 million new cases of tuberculosis (TB) every year, and there is an urgent need for better TB vaccines. TB vaccine candidates are selected for evaluation based in part on the detection of an antigen-specific gamma interferon (IFN-γ) response. The measurement of mycobacterial growth in blood specimens obtained from subjects immunized with investigational TB vaccines may be a better in vitro correlate of in vivo vaccine efficacy. We performed a clinical study with 30 United Kingdom adults who were followed for 6 months to evaluate the abilities of both a whole-blood- and a novel peripheral blood mononuclear cell (PBMC)-based mycobacterial growth inhibition assay to measure a response to primary vaccination and revaccination with BCG. Using cryopreserved PBMCs, we observed a significant improvement in mycobacterial growth inhibition following primary vaccination but no improvement in growth inhibition following revaccination with BCG (P < 0.05). Mycobacterial growth inhibition following primary BCG vaccination was not correlated with purified protein derivative (PPD) antigen-specific IFN-γ enzyme-linked immunospot (ELISPOT) responses. We demonstrate that a mycobacterial growth inhibition assay can detect improved capacity to control growth following primary immunization, but not revaccination, with BCG. This is the first study to demonstrate that an in vitro growth inhibition assay can identify a difference in vaccine responses by comparing both primary and secondary BCG vaccinations, suggesting that in vitro growth inhibition assays may serve as better surrogates of clinical efficacy than the assays currently used for the assessment of candidate TB vaccines." @default.
• W2123455592 created "2016-06-24" @default.
• W2123455592 creator A5005259317 @default.
• W2123455592 creator A5015141183 @default.
• W2123455592 creator A5017488931 @default.
• W2123455592 creator A5031637377 @default.
• W2123455592 creator A5032987607 @default.
• W2123455592 creator A5033942086 @default.
• W2123455592 creator A5046227670 @default.
• W2123455592 creator A5056365427 @default.
• W2123455592 creator A5056601950 @default.
• W2123455592 creator A5060825772 @default.
• W2123455592 creator A5069576329 @default.
• W2123455592 creator A5071879956 @default.
• W2123455592 creator A5077881101 @default.
• W2123455592 creator A5082085590 @default.
• W2123455592 creator A5089522455 @default.
• W2123455592 creator A5090963821 @default.
• W2123455592 date "2013-11-01" @default.
• W2123455592 modified "2023-10-12" @default.
• W2123455592 title "Inhibition of Mycobacterial Growth <i>In Vitro</i> following Primary but Not Secondary Vaccination with Mycobacterium bovis BCG" @default.
• W2123455592 cites W1966041933 @default.
• W2123455592 cites W1984899749 @default.
• W2123455592 cites W1986032732 @default.
• W2123455592 cites W1996209042 @default.
• W2123455592 cites W2003084960 @default.
• W2123455592 cites W2009517518 @default.
• W2123455592 cites W2015752737 @default.
• W2123455592 cites W2075477269 @default.
• W2123455592 cites W2103734560 @default.
• W2123455592 cites W2114677785 @default.
• W2123455592 cites W2122080673 @default.
• W2123455592 cites W2124515177 @default.
• W2123455592 cites W2130245215 @default.
• W2123455592 cites W2142183776 @default.
• W2123455592 cites W2144010669 @default.
• W2123455592 cites W2150707766 @default.
• W2123455592 cites W2151733890 @default.
• W2123455592 cites W2161910943 @default.
• W2123455592 cites W2164944419 @default.
• W2123455592 cites W2496549934 @default.
• W2123455592 doi "https://doi.org/10.1128/cvi.00427-13" @default.
• W2123455592 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3837779" @default.
• W2123455592 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23986316" @default.
• W2123455592 hasPublicationYear "2013" @default.
• W2123455592 type Work @default.
• W2123455592 sameAs 2123455592 @default.
• W2123455592 citedByCount "75" @default.
• W2123455592 countsByYear W21234555922013 @default.
• W2123455592 countsByYear W21234555922014 @default.
• W2123455592 countsByYear W21234555922015 @default.
• W2123455592 countsByYear W21234555922016 @default.
• W2123455592 countsByYear W21234555922017 @default.
• W2123455592 countsByYear W21234555922018 @default.
• W2123455592 countsByYear W21234555922019 @default.
• W2123455592 countsByYear W21234555922020 @default.
• W2123455592 countsByYear W21234555922021 @default.
• W2123455592 countsByYear W21234555922022 @default.
• W2123455592 countsByYear W21234555922023 @default.
• W2123455592 crossrefType "journal-article" @default.
• W2123455592 hasAuthorship W2123455592A5005259317 @default.
• W2123455592 hasAuthorship W2123455592A5015141183 @default.
• W2123455592 hasAuthorship W2123455592A5017488931 @default.
• W2123455592 hasAuthorship W2123455592A5031637377 @default.
• W2123455592 hasAuthorship W2123455592A5032987607 @default.
• W2123455592 hasAuthorship W2123455592A5033942086 @default.
• W2123455592 hasAuthorship W2123455592A5046227670 @default.
• W2123455592 hasAuthorship W2123455592A5056365427 @default.
• W2123455592 hasAuthorship W2123455592A5056601950 @default.
• W2123455592 hasAuthorship W2123455592A5060825772 @default.
• W2123455592 hasAuthorship W2123455592A5069576329 @default.
• W2123455592 hasAuthorship W2123455592A5071879956 @default.
• W2123455592 hasAuthorship W2123455592A5077881101 @default.
• W2123455592 hasAuthorship W2123455592A5082085590 @default.
• W2123455592 hasAuthorship W2123455592A5089522455 @default.
• W2123455592 hasAuthorship W2123455592A5090963821 @default.
• W2123455592 hasBestOaLocation W21234555921 @default.
• W2123455592 hasConcept C137061746 @default.
• W2123455592 hasConcept C142724271 @default.
• W2123455592 hasConcept C147483822 @default.
• W2123455592 hasConcept C150903083 @default.
• W2123455592 hasConcept C159047783 @default.
• W2123455592 hasConcept C167672396 @default.
• W2123455592 hasConcept C202751555 @default.
• W2123455592 hasConcept C203014093 @default.
• W2123455592 hasConcept C207001950 @default.
• W2123455592 hasConcept C22070199 @default.
• W2123455592 hasConcept C2777975735 @default.
• W2123455592 hasConcept C2778288313 @default.
• W2123455592 hasConcept C2778497218 @default.
• W2123455592 hasConcept C2779053233 @default.
• W2123455592 hasConcept C2780801004 @default.
• W2123455592 hasConcept C2780841837 @default.
• W2123455592 hasConcept C2781069245 @default.
• W2123455592 hasConcept C55493867 @default.
• W2123455592 hasConcept C71924100 @default.
• W2123455592 hasConcept C86803240 @default.
• W2123455592 hasConcept C8891405 @default.

• next