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- W2123460354 abstract "Salmonella strains that lack or overproduce DNA adenine methylase (Dam) elicit a protective immune response to different Salmonella species. To generate vaccines against other bacterial pathogens, the dam genes of Yersinia pseudotuberculosis and Vibrio cholerae were disrupted but found to be essential for viability. Overproduction of Dam significantly attenuated the virulence of these two pathogens, leading to, in Yersinia, the ectopic secretion of virulence proteins (Yersinia outer proteins) and a fully protective immune response in vaccinated hosts. Dysregulation of Dam activity may provide a means for the development of vaccines against varied bacterial pathogens." @default.
- W2123460354 created "2016-06-24" @default.
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- W2123460354 date "2001-12-01" @default.
- W2123460354 modified "2023-09-27" @default.
- W2123460354 title "DNA Adenine Methylase Is Essential for Viability and Plays a Role in the Pathogenesis of <i>Yersinia pseudotuberculosis</i> and <i>Vibrio cholerae</i>" @default.
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- W2123460354 doi "https://doi.org/10.1128/iai.69.12.7610-7615.2001" @default.
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