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• W2123461168 abstract "No AccessJournal of UrologyInvestigative Urology1 Sep 2015The Effects of RAAS Inhibition in Rate Limiting Step by Aliskiren on Testicular Torsion Injury in Rats Harun Un, Yasin Bayir, Zekai Halici, Erol Akpinar, Emre Karakus, Akgun Oral, Tevfik Ziypak, and Jale Selli Harun UnHarun Un Department of Biochemistry, Faculty of Pharmacy, Agri Ibrahim Cecen University, Agri, Turkey More articles by this author , Yasin BayirYasin Bayir Department of Biochemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey More articles by this author , Zekai HaliciZekai Halici Department of Pharmacology, Faculty of Medicine, Ataturk University, Erzurum, Turkey More articles by this author , Erol AkpinarErol Akpinar Department of Pharmacology, Faculty of Medicine, Ataturk University, Erzurum, Turkey More articles by this author , Emre KarakusEmre Karakus Department of Pharmacology and Toxicology, Faculty of Veterinary, Ataturk University, Erzurum, Turkey More articles by this author , Akgun OralAkgun Oral Department of Child Surgery, Faculty of Medicine, Ataturk University, Erzurum, Turkey More articles by this author , Tevfik ZiypakTevfik Ziypak Department of Urology, Faculty of Medicine, Ataturk University, Erzurum, Turkey More articles by this author , and Jale SelliJale Selli Department of Histology and Embryology, Faculty of Medicine, Ataturk University, Erzurum, Turkey More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.03.117AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Testicular torsion is a urological emergency. Failure of timely intervention for this issue leads the testicles to go into necrosis. If left untreated, it can lead to loss of the reproductive organs. The aim of this study was to examine the role of aliskiren in testicular torsion and detorsion injuries. Materials and Methods: Rats were divided into 8 groups of 12 each, including no torsion-detorsion, no torsion-detorsion plus 200 mg/kg aliskiren orally, torsion, torsion-detorsion, torsion plus 100 mg/kg aliskiren orally, torsion plus 200 mg/kg aliskiren orally, torsion-detorsion plus 100 mg/kg aliskiren orally and torsion-detorsion plus 200 mg/kg aliskiren orally. Aliskiren was administered 30 minutes before ischemia and reperfusion, and also 24 hours before the experimental protocol in all treatment groups. Ischemia and reperfusion were each applied for 2 hours. Results: Testicular damage decreased superoxide dismutase and glutathione, and increased malondialdehyde in the testis tissues of rats. Aliskiren administration increased superoxide dismutase and glutathione, and decreased malondialdehyde in the testis tissues. Values were measured by a biochemical autoanalyzer. In addition, this torsion-detorsion damage caused a significant increase in levels of the inflammatory cytokine and agents interleukin-1β and inducible nitric oxide synthase, as examined by real-time polymerase chain reaction. Aliskiren administration decreased these parameters. On pathological evaluation administration of a 200 mg/kg dose of aliskiren was found to protect the testis. Renin-angiotensin-aldosterone system inhibition by aliskiren caused an increase in serum renin levels and a decrease in serum angiotensin II levels. Conclusions: It appears that aliskiren protects the testis from ischemia-reperfusion damage by regulating inflammation and the oxidant-antioxidant balance via renin-angiotensin-aldosterone system inhibition. 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Google Scholar © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 194Issue 3September 2015Page: 828-833Supplementary Materials Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.Keywordsreperfusionspermatic cord torsiontestisischemiaaliskirenMetrics Author Information Harun Un Department of Biochemistry, Faculty of Pharmacy, Agri Ibrahim Cecen University, Agri, Turkey More articles by this author Yasin Bayir Department of Biochemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey More articles by this author Zekai Halici Department of Pharmacology, Faculty of Medicine, Ataturk University, Erzurum, Turkey More articles by this author Erol Akpinar Department of Pharmacology, Faculty of Medicine, Ataturk University, Erzurum, Turkey More articles by this author Emre Karakus Department of Pharmacology and Toxicology, Faculty of Veterinary, Ataturk University, Erzurum, Turkey More articles by this author Akgun Oral Department of Child Surgery, Faculty of Medicine, Ataturk University, Erzurum, Turkey More articles by this author Tevfik Ziypak Department of Urology, Faculty of Medicine, Ataturk University, Erzurum, Turkey More articles by this author Jale Selli Department of Histology and Embryology, Faculty of Medicine, Ataturk University, Erzurum, Turkey More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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