FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123465720> ?p ?o ?g. }

• W2123465720 endingPage "89" @default.
• W2123465720 startingPage "81" @default.
• W2123465720 abstract "Aminoguanidine, an inhibitor of advanced glycation reactions in vitro, inhibits the development of diabetic complications in animal models of diabetes, suggesting that it acts by inhibition of advanced glycation reactions in vivo. However, effects of aminoguanidine on the formation of specific advanced glycation end-products (AGEs) in vivo have not been rigorously examined. Therefore, we studied the effects of aminoguanidine on the formation of pentosidine and Nε-(carboxymethyl)lysine (CML), measured by analytical chemical methods, in collagen of streptozotocin-diabetic Lewis rats at doses which ameliorated urinary albumin excretion, an index of diabetic nephropathy. At 12 weeks, diabetic animals had fivefold higher blood glucose, threefold higher glycated hemoglobin and fivefold higher collagen glycation, compared to metabolically healthy controls; pentosidine and CML in skin collagen were increased by approximately 30 and 150%, respectively. Administration of aminoguanidine, 50 mg/kg by daily intraperitoneal injection, significantly inhibited the development of albuminuria (≈60%, P<0.01) in diabetic rats, without an effect on blood glucose or glycation of hemoglobin or collagen. Surprisingly, aminoguanidine failed to inhibit the increase in pentosidine and CML in diabetic rat skin collagen. Similar results were obtained in an independent experiment in which aminoguanidine was administered in drinking water at a dose of 0.5 g/l. We conclude that the therapeutic benefits of aminoguanidine on albuminuria may not be the result of inhibition of AGE formation." @default.
• W2123465720 created "2016-06-24" @default.
• W2123465720 creator A5001291710 @default.
• W2123465720 creator A5009891314 @default.
• W2123465720 creator A5012752158 @default.
• W2123465720 creator A5017656696 @default.
• W2123465720 creator A5037548013 @default.
• W2123465720 creator A5049311994 @default.
• W2123465720 creator A5068329483 @default.
• W2123465720 creator A5087140822 @default.
• W2123465720 creator A5090104145 @default.
• W2123465720 date "1999-02-01" @default.
• W2123465720 modified "2023-10-16" @default.
• W2123465720 title "Aminoguanidine inhibits albuminuria, but not the formation of advanced glycation end-products in skin collagen of diabetic rats" @default.
• W2123465720 cites W1532082751 @default.
• W2123465720 cites W1557253076 @default.
• W2123465720 cites W1564784842 @default.
• W2123465720 cites W1609735481 @default.
• W2123465720 cites W1969739712 @default.
• W2123465720 cites W1974804971 @default.
• W2123465720 cites W1983286905 @default.
• W2123465720 cites W1985545824 @default.
• W2123465720 cites W1993736540 @default.
• W2123465720 cites W2007804077 @default.
• W2123465720 cites W2010707246 @default.
• W2123465720 cites W2011496359 @default.
• W2123465720 cites W2017214714 @default.
• W2123465720 cites W2024542927 @default.
• W2123465720 cites W2026703782 @default.
• W2123465720 cites W2032055976 @default.
• W2123465720 cites W2041152575 @default.
• W2123465720 cites W2048441160 @default.
• W2123465720 cites W2052059287 @default.
• W2123465720 cites W2052681712 @default.
• W2123465720 cites W2056903490 @default.
• W2123465720 cites W2064846855 @default.
• W2123465720 cites W2067246958 @default.
• W2123465720 cites W2071438280 @default.
• W2123465720 cites W2076195680 @default.
• W2123465720 cites W2084126217 @default.
• W2123465720 cites W2084380663 @default.
• W2123465720 cites W2085612615 @default.
• W2123465720 cites W2088844252 @default.
• W2123465720 cites W2090635246 @default.
• W2123465720 cites W2093636423 @default.
• W2123465720 cites W2093948067 @default.
• W2123465720 cites W2108448809 @default.
• W2123465720 cites W2111867309 @default.
• W2123465720 cites W2112660114 @default.
• W2123465720 cites W2158541945 @default.
• W2123465720 cites W2159098534 @default.
• W2123465720 cites W3024383408 @default.
• W2123465720 cites W4231758317 @default.
• W2123465720 cites W4235552555 @default.
• W2123465720 cites W4239792441 @default.
• W2123465720 cites W4241274181 @default.
• W2123465720 cites W4249223069 @default.
• W2123465720 cites W4249803154 @default.
• W2123465720 cites W4251350326 @default.
• W2123465720 cites W4254523290 @default.
• W2123465720 doi "https://doi.org/10.1016/s0168-8227(98)00121-1" @default.
• W2123465720 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10221660" @default.
• W2123465720 hasPublicationYear "1999" @default.
• W2123465720 type Work @default.
• W2123465720 sameAs 2123465720 @default.
• W2123465720 citedByCount "34" @default.
• W2123465720 countsByYear W21234657202012 @default.
• W2123465720 countsByYear W21234657202015 @default.
• W2123465720 countsByYear W21234657202016 @default.
• W2123465720 countsByYear W21234657202017 @default.
• W2123465720 countsByYear W21234657202018 @default.
• W2123465720 countsByYear W21234657202019 @default.
• W2123465720 countsByYear W21234657202022 @default.
• W2123465720 crossrefType "journal-article" @default.
• W2123465720 hasAuthorship W2123465720A5001291710 @default.
• W2123465720 hasAuthorship W2123465720A5009891314 @default.
• W2123465720 hasAuthorship W2123465720A5012752158 @default.
• W2123465720 hasAuthorship W2123465720A5017656696 @default.
• W2123465720 hasAuthorship W2123465720A5037548013 @default.
• W2123465720 hasAuthorship W2123465720A5049311994 @default.
• W2123465720 hasAuthorship W2123465720A5068329483 @default.
• W2123465720 hasAuthorship W2123465720A5087140822 @default.
• W2123465720 hasAuthorship W2123465720A5090104145 @default.
• W2123465720 hasConcept C126322002 @default.
• W2123465720 hasConcept C134018914 @default.
• W2123465720 hasConcept C147990577 @default.
• W2123465720 hasConcept C150903083 @default.
• W2123465720 hasConcept C207001950 @default.
• W2123465720 hasConcept C2776174234 @default.
• W2123465720 hasConcept C2776997535 @default.
• W2123465720 hasConcept C2777180221 @default.
• W2123465720 hasConcept C2777538456 @default.
• W2123465720 hasConcept C2778917026 @default.
• W2123465720 hasConcept C2779280383 @default.
• W2123465720 hasConcept C2779922275 @default.
• W2123465720 hasConcept C2780758796 @default.
• W2123465720 hasConcept C555293320 @default.
• W2123465720 hasConcept C71924100 @default.

• next