Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123469081> ?p ?o ?g. }
- W2123469081 endingPage "717" @default.
- W2123469081 startingPage "702" @default.
- W2123469081 abstract "Acetylsalicylic acid (ASA), also known as aspirin, a classic, nonsteroidal, anti-inflammatory drug (NSAID), is widely used to relieve minor aches and pains and to reduce fever. Epidemiological studies and other experimental studies suggest that ASA use reduces the risk of different cancers including breast cancer (BC) and may be used as a chemopreventive agent against BC and other cancers. These studies have raised the tempting possibility that ASA could serve as a preventive medicine for BC. However, lack of in-depth knowledge of the mechanism of action of ASA reshapes the debate of risk and benefit of using ASA in prevention of BC. Our studies, using in vitro and in vivo tumor xenograft models, show a strong beneficial effect of ASA in the prevention of breast carcinogenesis. We find that ASA not only prevents breast tumor cell growth in vitro and tumor growth in nude mice xenograft model through the induction of apoptosis, but also significantly reduces the self-renewal capacity and growth of breast tumor-initiating cells (BTICs)/breast cancer stem cells (BCSCs) and delays the formation of a palpable tumor. Moreover, ASA regulates other pathophysiological events in breast carcinogenesis, such as reprogramming the mesenchymal to epithelial transition (MET) and delaying in vitro migration in BC cells. The tumor growth-inhibitory and reprogramming roles of ASA could be mediated through inhibition of TGF-β/SMAD4 signaling pathway that is associated with growth, motility, invasion, and metastasis in advanced BCs. Collectively, ASA has a therapeutic or preventive potential by attacking possible target such as TGF-β in breast carcinogenesis." @default.
- W2123469081 created "2016-06-24" @default.
- W2123469081 creator A5002984064 @default.
- W2123469081 creator A5031790946 @default.
- W2123469081 creator A5038008974 @default.
- W2123469081 creator A5038396627 @default.
- W2123469081 creator A5052012148 @default.
- W2123469081 creator A5056858363 @default.
- W2123469081 date "2015-07-01" @default.
- W2123469081 modified "2023-10-02" @default.
- W2123469081 title "Aspirin blocks growth of breast tumor cells and tumor-initiating cells and induces reprogramming factors of mesenchymal to epithelial transition" @default.
- W2123469081 cites W1558367558 @default.
- W2123469081 cites W1565561072 @default.
- W2123469081 cites W1941165529 @default.
- W2123469081 cites W1968810018 @default.
- W2123469081 cites W1971092719 @default.
- W2123469081 cites W1973890143 @default.
- W2123469081 cites W1983018567 @default.
- W2123469081 cites W1985466103 @default.
- W2123469081 cites W1987837071 @default.
- W2123469081 cites W1988518646 @default.
- W2123469081 cites W1989584350 @default.
- W2123469081 cites W1989588315 @default.
- W2123469081 cites W1992241296 @default.
- W2123469081 cites W1993497779 @default.
- W2123469081 cites W1994888307 @default.
- W2123469081 cites W1999155906 @default.
- W2123469081 cites W2008190138 @default.
- W2123469081 cites W2011530250 @default.
- W2123469081 cites W2017990196 @default.
- W2123469081 cites W2023032672 @default.
- W2123469081 cites W2023427658 @default.
- W2123469081 cites W2023539195 @default.
- W2123469081 cites W2023826235 @default.
- W2123469081 cites W2025690227 @default.
- W2123469081 cites W2029669343 @default.
- W2123469081 cites W2033424069 @default.
- W2123469081 cites W2033459915 @default.
- W2123469081 cites W2035729473 @default.
- W2123469081 cites W2040430549 @default.
- W2123469081 cites W2044426488 @default.
- W2123469081 cites W2046425054 @default.
- W2123469081 cites W2051672403 @default.
- W2123469081 cites W2053630170 @default.
- W2123469081 cites W2055498399 @default.
- W2123469081 cites W2056422550 @default.
- W2123469081 cites W2056709081 @default.
- W2123469081 cites W2059174198 @default.
- W2123469081 cites W2060315334 @default.
- W2123469081 cites W2060533030 @default.
- W2123469081 cites W2063432148 @default.
- W2123469081 cites W2068881271 @default.
- W2123469081 cites W2071881303 @default.
- W2123469081 cites W2080232352 @default.
- W2123469081 cites W2093468591 @default.
- W2123469081 cites W2096021974 @default.
- W2123469081 cites W2099567217 @default.
- W2123469081 cites W2101071796 @default.
- W2123469081 cites W2113638068 @default.
- W2123469081 cites W2113704788 @default.
- W2123469081 cites W2113841348 @default.
- W2123469081 cites W2114120215 @default.
- W2123469081 cites W2121836743 @default.
- W2123469081 cites W2123955887 @default.
- W2123469081 cites W2127617517 @default.
- W2123469081 cites W2132799399 @default.
- W2123469081 cites W2133586647 @default.
- W2123469081 cites W2138039462 @default.
- W2123469081 cites W2138824201 @default.
- W2123469081 cites W2145374398 @default.
- W2123469081 cites W2150966393 @default.
- W2123469081 cites W2153641624 @default.
- W2123469081 cites W2154554320 @default.
- W2123469081 cites W2157304020 @default.
- W2123469081 cites W2158718772 @default.
- W2123469081 cites W2159640574 @default.
- W2123469081 cites W2163158525 @default.
- W2123469081 cites W2165948908 @default.
- W2123469081 cites W2166644606 @default.
- W2123469081 cites W2170372544 @default.
- W2123469081 cites W2170471719 @default.
- W2123469081 cites W91313376 @default.
- W2123469081 doi "https://doi.org/10.1038/labinvest.2015.49" @default.
- W2123469081 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25867761" @default.
- W2123469081 hasPublicationYear "2015" @default.
- W2123469081 type Work @default.
- W2123469081 sameAs 2123469081 @default.
- W2123469081 citedByCount "61" @default.
- W2123469081 countsByYear W21234690812015 @default.
- W2123469081 countsByYear W21234690812016 @default.
- W2123469081 countsByYear W21234690812017 @default.
- W2123469081 countsByYear W21234690812018 @default.
- W2123469081 countsByYear W21234690812019 @default.
- W2123469081 countsByYear W21234690812020 @default.
- W2123469081 countsByYear W21234690812021 @default.
- W2123469081 countsByYear W21234690812022 @default.
- W2123469081 countsByYear W21234690812023 @default.
- W2123469081 crossrefType "journal-article" @default.