FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123478110> ?p ?o ?g. }

• W2123478110 endingPage "2749" @default.
• W2123478110 startingPage "2733" @default.
• W2123478110 abstract "The real-time dynamics of the T cell receptor (TCR) reflect antigen detection and T cell signaling, providing valuable insight into the evolving events of the immune response. Despite considerable advances in studying TCR dynamics in simplified systems in vitro, live imaging of subcellular signaling complexes expressed at physiological densities in intact tissues has been challenging. In this study, we generated a transgenic mouse with a TCR fused to green fluorescent protein to provide insight into the early signaling events of the immune response. To enable imaging of TCR dynamics in naive T cells in the lymph node, we enhanced signal detection of the fluorescent TCR fusion protein and used volumetric masking with a second fluorophore to mark the T cells expressing the fluorescent TCR. These in vivo analyses and parallel experiments in vitro show minimal and transient incorporation of TCRs into a stable central supramolecular activating cluster (cSMAC) structure but strong evidence for rapid, antigen-dependent TCR internalization that was not contingent on T cell motility arrest or cSMAC formation. Short-lived antigen-independent TCR clustering was also occasionally observed. These in vivo observations demonstrate that varied TCR trafficking and cell arrest dynamics occur during early T cell activation." @default.
• W2123478110 created "2016-06-24" @default.
• W2123478110 creator A5008625070 @default.
• W2123478110 creator A5018179968 @default.
• W2123478110 creator A5027358643 @default.
• W2123478110 creator A5063202361 @default.
• W2123478110 creator A5076736469 @default.
• W2123478110 date "2010-11-01" @default.
• W2123478110 modified "2023-10-14" @default.
• W2123478110 title "Real-time analysis of T cell receptors in naive cells in vitro and in vivo reveals flexibility in synapse and signaling dynamics" @default.
• W2123478110 cites W1518539840 @default.
• W2123478110 cites W1562441478 @default.
• W2123478110 cites W1564175926 @default.
• W2123478110 cites W1902251032 @default.
• W2123478110 cites W1959677146 @default.
• W2123478110 cites W1974374103 @default.
• W2123478110 cites W1976852696 @default.
• W2123478110 cites W1982905247 @default.
• W2123478110 cites W1987625947 @default.
• W2123478110 cites W1988009411 @default.
• W2123478110 cites W1990458269 @default.
• W2123478110 cites W1991593737 @default.
• W2123478110 cites W2000269493 @default.
• W2123478110 cites W2007988618 @default.
• W2123478110 cites W2015776459 @default.
• W2123478110 cites W2018947464 @default.
• W2123478110 cites W2024957425 @default.
• W2123478110 cites W2028968136 @default.
• W2123478110 cites W2034402052 @default.
• W2123478110 cites W2043893491 @default.
• W2123478110 cites W2047488334 @default.
• W2123478110 cites W2049815306 @default.
• W2123478110 cites W2053817261 @default.
• W2123478110 cites W2053942778 @default.
• W2123478110 cites W2056207883 @default.
• W2123478110 cites W2058750126 @default.
• W2123478110 cites W2064593553 @default.
• W2123478110 cites W2067006556 @default.
• W2123478110 cites W2076171916 @default.
• W2123478110 cites W2088939947 @default.
• W2123478110 cites W2093422329 @default.
• W2123478110 cites W2096234619 @default.
• W2123478110 cites W2107919289 @default.
• W2123478110 cites W2115664739 @default.
• W2123478110 cites W2115759372 @default.
• W2123478110 cites W2119879881 @default.
• W2123478110 cites W2131905612 @default.
• W2123478110 cites W2136029016 @default.
• W2123478110 cites W2137066068 @default.
• W2123478110 cites W2140636977 @default.
• W2123478110 cites W2141354546 @default.
• W2123478110 cites W2149928606 @default.
• W2123478110 cites W2153312701 @default.
• W2123478110 cites W2155556393 @default.
• W2123478110 cites W2158421588 @default.
• W2123478110 cites W2167670122 @default.
• W2123478110 cites W2176642182 @default.
• W2123478110 doi "https://doi.org/10.1084/jem.20091201" @default.
• W2123478110 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2989766" @default.
• W2123478110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21041455" @default.
• W2123478110 hasPublicationYear "2010" @default.
• W2123478110 type Work @default.
• W2123478110 sameAs 2123478110 @default.
• W2123478110 citedByCount "84" @default.
• W2123478110 countsByYear W21234781102012 @default.
• W2123478110 countsByYear W21234781102013 @default.
• W2123478110 countsByYear W21234781102014 @default.
• W2123478110 countsByYear W21234781102015 @default.
• W2123478110 countsByYear W21234781102016 @default.
• W2123478110 countsByYear W21234781102017 @default.
• W2123478110 countsByYear W21234781102018 @default.
• W2123478110 countsByYear W21234781102019 @default.
• W2123478110 countsByYear W21234781102020 @default.
• W2123478110 countsByYear W21234781102021 @default.
• W2123478110 countsByYear W21234781102022 @default.
• W2123478110 countsByYear W21234781102023 @default.
• W2123478110 crossrefType "journal-article" @default.
• W2123478110 hasAuthorship W2123478110A5008625070 @default.
• W2123478110 hasAuthorship W2123478110A5018179968 @default.
• W2123478110 hasAuthorship W2123478110A5027358643 @default.
• W2123478110 hasAuthorship W2123478110A5063202361 @default.
• W2123478110 hasAuthorship W2123478110A5076736469 @default.
• W2123478110 hasBestOaLocation W21234781101 @default.
• W2123478110 hasConcept C139770010 @default.
• W2123478110 hasConcept C147483822 @default.
• W2123478110 hasConcept C1491633281 @default.
• W2123478110 hasConcept C19317047 @default.
• W2123478110 hasConcept C203014093 @default.
• W2123478110 hasConcept C2776090121 @default.
• W2123478110 hasConcept C55493867 @default.
• W2123478110 hasConcept C86803240 @default.
• W2123478110 hasConcept C8891405 @default.
• W2123478110 hasConcept C95444343 @default.
• W2123478110 hasConcept C9756297 @default.
• W2123478110 hasConceptScore W2123478110C139770010 @default.
• W2123478110 hasConceptScore W2123478110C147483822 @default.
• W2123478110 hasConceptScore W2123478110C1491633281 @default.
• W2123478110 hasConceptScore W2123478110C19317047 @default.

• next