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- W2123485996 abstract "Gonadal function declines with aging in women and men. Although the decrease in ovarian estrogen production occurs at the menopause in a dramatic, universal, and relatively brief time-limited manner, the decline in testosterone secretion known as the andropause develops slowly over several decades in most, but certainly not all, men. Serum total testosterone levels decline at a constant rate from the mid-thirties onward in healthy men. By the age of 70 years, only 1 in 5 men has a total testosterone level that is lower than normal, but by the ninth decade of life, 50% of men have low total testosterone levels, and more than 90% have a free testosterone index that is low (1). Because many of the catabolic sequelae associated with aging, such as sarcopenia, increased adiposity, and osteoporosis, are similar to those seen in hypogonadal young men, it has been tempting to recommend treating andropausal men with testosterone replacement therapy in a manner analogous to treating postmenopausal women with estrogenic compounds. Moreover, the successful use of androgens to treat wasting related to infection with human immunodeficiency virus (HIV) infection has renewed the argument that androgen therapy might prove useful to combat frailty in aging men and women (2)." @default.
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- W2123485996 date "2001-09-01" @default.
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- W2123485996 title "Should we treat the andropause?" @default.
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- W2123485996 doi "https://doi.org/10.1016/s0002-9343(01)00888-9" @default.
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