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• W2123505394 abstract "Many systems regulating cell polarity involve stable landmarks defined by internal cues [1Petrie R.J. Doyle A.D. Yamada K.M. Random versus directionally persistent cell migration.Nat. Rev. Mol. Cell Biol. 2009; 10: 538-549Crossref PubMed Scopus (705) Google Scholar, 2Cheung A.Y. Duan Q.H. Costa S.S. de Graaf B.H. Di Stilio V.S. Feijo J. Wu H.M. The dynamic pollen tube cytoskeleton: Live cell studies using actin-binding and microtubule-binding reporter proteins.Mol. Plant. 2008; 1: 686-702Abstract Full Text Full Text PDF PubMed Scopus (85) Google Scholar, 3Fischer R. Zekert N. Takeshita N. Polarized growth in fungi–interplay between the cytoskeleton, positional markers and membrane domains.Mol. Microbiol. 2008; 68: 813-826Crossref PubMed Scopus (154) Google Scholar, 4Siegrist S.E. Doe C.Q. Microtubule-induced cortical cell polarity.Genes Dev. 2007; 21: 483-496Crossref PubMed Scopus (200) Google Scholar, 5Basu R. Chang F. Shaping the actin cytoskeleton using microtubule tips.Curr. Opin. Cell Biol. 2007; 19: 88-94Crossref PubMed Scopus (65) Google Scholar]. In the rod-shaped fission yeast Schizosaccharomyces pombe, microtubules regulate polarized vegetative growth via a landmark involving the protein Tea1 [6Mata J. Nurse P. tea1 and the microtubular cytoskeleton are important for generating global spatial order within the fission yeast cell.Cell. 1997; 89: 939-949Abstract Full Text Full Text PDF PubMed Scopus (304) Google Scholar, 7Sawin K.E. Snaith H.A. Role of microtubules and tea1p in establishment and maintenance of fission yeast cell polarity.J. Cell Sci. 2004; 117: 689-700Crossref PubMed Scopus (70) Google Scholar, 8Piel M. Tran P.T. Cell shape and cell division in fission yeast.Curr. Biol. 2009; 19: R823-R827Abstract Full Text Full Text PDF PubMed Scopus (47) Google Scholar, 9Minc N. Bratman S.V. Basu R. Chang F. Establishing new sites of polarization by microtubules.Curr. Biol. 2009; 19: 83-94Abstract Full Text Full Text PDF PubMed Scopus (66) Google Scholar]. Tea1 is delivered to cell tips as packets of molecules associated with growing microtubule ends [10Behrens R. Nurse P. Roles of fission yeast tea1p in the localization of polarity factors and in organizing the microtubular cytoskeleton.J. Cell Biol. 2002; 157: 783-793Crossref PubMed Scopus (78) Google Scholar] and anchored at the plasma membrane via a mechanism involving interaction with the membrane protein Mod5 [11Snaith H.A. Sawin K.E. Fission yeast mod5p regulates polarized growth through anchoring of tea1p at cell tips.Nature. 2003; 423: 647-651Crossref PubMed Scopus (107) Google Scholar, 12Snaith H.A. Samejima I. Sawin K.E. Multistep and multimode cortical anchoring of tea1p at cell tips in fission yeast.EMBO J. 2005; 24: 3690-3699Crossref PubMed Scopus (74) Google Scholar]. Tea1 and Mod5 are highly concentrated in clusters at cell tips in a mutually dependent manner, but how the Tea1-Mod5 interaction contributes mechanistically to generating a stable landmark is not understood. Here, we use live-cell imaging, FRAP, and computational modeling to dissect dynamics of the Tea1-Mod5 interaction. Surprisingly, we find that Tea1 and Mod5 exhibit distinctly different turnover rates at cell tips. Our data and modeling suggest that rather than acting simply as a Tea1 receptor or as a molecular “glue” to retain Tea1, Mod5 functions catalytically to stimulate incorporation of Tea1 into a stable tip-associated cluster network. The model also suggests an emergent self-focusing property of the Tea1-Mod5 cluster network, which can increase the fidelity of polarized growth." @default.
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• W2123505394 date "2010-10-01" @default.
• W2123505394 modified "2023-10-16" @default.
• W2123505394 title "A Catalytic Role for Mod5 in the Formation of the Tea1 Cell Polarity Landmark" @default.
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• W2123505394 doi "https://doi.org/10.1016/j.cub.2010.08.035" @default.
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