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- W2123507320 abstract "The efficacy of orally administered mycophenolic acid (MPA), an inhibitor of guanosine monophosphate (GMP) synthesis, for the treatment of psoriasis, was studied in a double-blind fashion. Of twenty-one patients completing the study period, ten of eleven patients treated with MPA had a greater than 25% decrease in severity score compared with only two of ten patients treated with placebo. The placebo group had a slight increase in severity score compared to almost 50% reduction in the average severity score of the MPA-treated group. After termination of the double-blind portion of the study, the placebo group was treated with MPA and showed a 60% decrease in severity score. Adverse effects encountered included anorexia, nausea, vomiting, and diarrhea. One patient had an uncomplicated episode of herpes zoster. Other than a mild decrease hemoglobin, no hematologic toxicity was noted." @default.
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- W2123507320 date "1979-12-01" @default.
- W2123507320 modified "2023-09-24" @default.
- W2123507320 title "Efficacy of mycophenolic acid for the treatment of psoriasis" @default.
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- W2123507320 doi "https://doi.org/10.1016/s0190-9622(79)80097-3" @default.
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