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• W2123529713 abstract "Non-ionic, water-soluble radiographic contrast media have been suggested as intestinal permeability probes. We studied the permeability of the isosmolar contrast medium iodixanol and 51Cr-labeled ethylenediaminetetraacetic acid (EDTA) from the non-perforated colon after induction of colonic inflammation.Colonic inflammation and ulcerations were induced by luminal colonic instillation of trinitrobenzenesulfonic acid, dissolved in 40% ethanol. Controls received saline. Fourteen days later iodixanol, 320 mg I/ml, and 51Cr-EDTA were given as an enema. Urine was collected for the subsequent 6 h and subjected to high-performance liquid chromatography and gamma activity counting.Urinary recovery of iodixanol and 51Cr-EDTA increased gradually with severity of the colonic inflammation. The correlation between iodixanol and 51Cr-EDTA recovery was strong (corr.coeff = 0.97).Iodixanol shows as good properties as 51Cr-EDTA when used as intestinal permeability probe in the inflamed and ulcerated rat colon. Use of the radiopaque properties of iodixanol enable intestinal probe exposure registration by film or fluoroscopy." @default.
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• W2123529713 date "1996-01-01" @default.
• W2123529713 modified "2023-09-27" @default.
• W2123529713 title "The X-Ray Contrast Medium Iodixanol Detects Increased Colonic Permeability Equally Well as51Cr-labeled Ethylenediaminetetraacetic Acid in Experimental Colitis of Rats" @default.
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• W2123529713 doi "https://doi.org/10.3109/00365529609031978" @default.
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