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• W2123548878 startingPage "779" @default.
• W2123548878 abstract "Chlamydiae are a group of obligate intracellular bacteria comprising important human and animal pathogens as well as symbionts of ubiquitous protists. They are characterized by a developmental cycle including two main morphologically and physiologically distinct stages, the replicating reticulate body and the infectious nondividing elementary body. In this review, we reconstruct the history of studies that have led to our current perception of chlamydial physiology, focusing on their energy and central carbon metabolism. We then compare the metabolic capabilities of pathogenic and environmental chlamydiae highlighting interspecies variability among the metabolically more flexible environmental strains. We discuss recent findings suggesting that chlamydiae may not live as energy parasites throughout the developmental cycle and that elementary bodies are not metabolically inert but exhibit metabolic activity under appropriate axenic conditions. The observed host-free metabolic activity of elementary bodies may reflect adequate recapitulation of the intracellular environment, but there is evidence that this activity is biologically relevant and required for extracellular survival and maintenance of infectivity. The recent discoveries call for a reconsideration of chlamydial metabolism and future in-depth analyses to better understand how species- and stage-specific differences in chlamydial physiology may affect virulence, tissue tropism, and host adaptation." @default.
• W2123548878 created "2016-06-24" @default.
• W2123548878 creator A5007943621 @default.
• W2123548878 creator A5009906442 @default.
• W2123548878 creator A5016800306 @default.
• W2123548878 creator A5051283258 @default.
• W2123548878 date "2014-07-01" @default.
• W2123548878 modified "2023-10-11" @default.
• W2123548878 title "Chlamydial metabolism revisited: interspecies metabolic variability and developmental stage-specific physiologic activities" @default.
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