FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123599105> ?p ?o ?g. }

• W2123599105 endingPage "e401" @default.
• W2123599105 startingPage "e401" @default.
• W2123599105 abstract "In addition to the classical motor symptoms, motivational and affective deficits are core impairments of Parkinson's disease (PD). We recently demonstrated, by lesional approaches in rats, that degeneration of the substantia nigra pars compacta (SNc) dopaminergic (DA) neurons is likely to have a crucial role in the development of these neuropsychiatry symptoms. We have also shown that, as in clinical investigations, chronic treatment with levodopa or the DA D2/D3 receptor (D2/D3R) agonist ropinirole specifically reverses these PD-related motivational deficits. The roles of specific DA receptor subtypes in such reversal effects remain, however, unknown. We therefore investigated here the precise involvement of D1, D2 and D3R in the reversal of the motivational and affective deficits related to SNc DA neuronal loss. Three weeks after bilateral and partial 6-hydroxydopamine (6-OHDA) SNc lesions, rats received 14 daily intraperitoneal administrations of the selective D1R agonist SKF-38393 (2.5 or 3.5 mg kg−1), the selective D2R agonist sumanirole (0.1 or 0.15 mg kg−1), or the preferring D3R gonist PD-128907 (0.1 or 0.15 mg kg−1). Anxiety-, depressive-like and motivated behaviors were assessed in an elevated-plus maze, a forced-swim test, and an operant sucrose self-administration procedure, respectively. All DA agonists attenuated anxiety- and depressive-like behaviors. However, only PD-128907 reversed the motivational deficits induced by 6-OHDA SNc lesions. This effect was blocked by a selective D3R (SB-277011A, 10 mg kg−1), but not D2R (L-741,626, 1.5 mg kg−1), antagonist. These data provide strong evidence for the role of D3R in motivational processes and identify this receptor as a potentially valuable target for the treatment of PD-related neuropsychiatric symptoms." @default.
• W2123599105 created "2016-06-24" @default.
• W2123599105 creator A5018955311 @default.
• W2123599105 creator A5034602715 @default.
• W2123599105 creator A5037569073 @default.
• W2123599105 creator A5060175791 @default.
• W2123599105 creator A5061400306 @default.
• W2123599105 creator A5070947328 @default.
• W2123599105 creator A5089019474 @default.
• W2123599105 date "2014-06-17" @default.
• W2123599105 modified "2023-10-17" @default.
• W2123599105 title "Implication of dopamine D3 receptor activation in the reversion of Parkinson’s disease-related motivational deficits" @default.
• W2123599105 cites W1481581387 @default.
• W2123599105 cites W1642086117 @default.
• W2123599105 cites W1872057083 @default.
• W2123599105 cites W1937880349 @default.
• W2123599105 cites W194835070 @default.
• W2123599105 cites W1967332436 @default.
• W2123599105 cites W1969107429 @default.
• W2123599105 cites W1969748095 @default.
• W2123599105 cites W1972696687 @default.
• W2123599105 cites W1975553942 @default.
• W2123599105 cites W1975667546 @default.
• W2123599105 cites W1981821582 @default.
• W2123599105 cites W1982921548 @default.
• W2123599105 cites W1985760248 @default.
• W2123599105 cites W1985871295 @default.
• W2123599105 cites W1991505529 @default.
• W2123599105 cites W2003116007 @default.
• W2123599105 cites W2004485148 @default.
• W2123599105 cites W2020522596 @default.
• W2123599105 cites W2022153650 @default.
• W2123599105 cites W2028980996 @default.
• W2123599105 cites W2030378570 @default.
• W2123599105 cites W2037277347 @default.
• W2123599105 cites W2040625330 @default.
• W2123599105 cites W2042491822 @default.
• W2123599105 cites W2050123286 @default.
• W2123599105 cites W2053959292 @default.
• W2123599105 cites W2056162837 @default.
• W2123599105 cites W2056669048 @default.
• W2123599105 cites W2058390517 @default.
• W2123599105 cites W2064116250 @default.
• W2123599105 cites W2064758007 @default.
• W2123599105 cites W2081729069 @default.
• W2123599105 cites W2086641444 @default.
• W2123599105 cites W2090518397 @default.
• W2123599105 cites W2097744565 @default.
• W2123599105 cites W2097871535 @default.
• W2123599105 cites W2101206139 @default.
• W2123599105 cites W2104523108 @default.
• W2123599105 cites W2110971533 @default.
• W2123599105 cites W2117782909 @default.
• W2123599105 cites W2118502552 @default.
• W2123599105 cites W2125393689 @default.
• W2123599105 cites W2134243390 @default.
• W2123599105 cites W2135101202 @default.
• W2123599105 cites W2146403799 @default.
• W2123599105 cites W2147385857 @default.
• W2123599105 cites W2147493925 @default.
• W2123599105 cites W2149695930 @default.
• W2123599105 cites W2154092962 @default.
• W2123599105 cites W2156411508 @default.
• W2123599105 cites W2167487498 @default.
• W2123599105 cites W2167497731 @default.
• W2123599105 cites W3022052974 @default.
• W2123599105 doi "https://doi.org/10.1038/tp.2014.43" @default.
• W2123599105 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4080324" @default.
• W2123599105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24937095" @default.
• W2123599105 hasPublicationYear "2014" @default.
• W2123599105 type Work @default.
• W2123599105 sameAs 2123599105 @default.
• W2123599105 citedByCount "48" @default.
• W2123599105 countsByYear W21235991052015 @default.
• W2123599105 countsByYear W21235991052016 @default.
• W2123599105 countsByYear W21235991052017 @default.
• W2123599105 countsByYear W21235991052018 @default.
• W2123599105 countsByYear W21235991052019 @default.
• W2123599105 countsByYear W21235991052020 @default.
• W2123599105 countsByYear W21235991052021 @default.
• W2123599105 countsByYear W21235991052022 @default.
• W2123599105 countsByYear W21235991052023 @default.
• W2123599105 crossrefType "journal-article" @default.
• W2123599105 hasAuthorship W2123599105A5018955311 @default.
• W2123599105 hasAuthorship W2123599105A5034602715 @default.
• W2123599105 hasAuthorship W2123599105A5037569073 @default.
• W2123599105 hasAuthorship W2123599105A5060175791 @default.
• W2123599105 hasAuthorship W2123599105A5061400306 @default.
• W2123599105 hasAuthorship W2123599105A5070947328 @default.
• W2123599105 hasAuthorship W2123599105A5089019474 @default.
• W2123599105 hasBestOaLocation W21235991051 @default.
• W2123599105 hasConcept C126322002 @default.
• W2123599105 hasConcept C134018914 @default.
• W2123599105 hasConcept C137183658 @default.
• W2123599105 hasConcept C15744967 @default.
• W2123599105 hasConcept C169760540 @default.
• W2123599105 hasConcept C170493617 @default.
• W2123599105 hasConcept C199596767 @default.

• next