Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123611234> ?p ?o ?g. }
- W2123611234 abstract "Evidence suggests a striking causal relationship between changes in quality control of neuronal mitochondria and numerous devastating human neurodegenerative diseases, including Parkinson's disease, Alzheimer's disease, Huntington's disease, and amyotrophic lateral sclerosis. Contrary to replicating mammalian cells with a metabolism essentially glycolytic, post-mitotic neurons are distinctive owing to (i) their exclusive energetic dependence from mitochondrial metabolism and (ii) their polarized shape, which entails compartmentalized and distinct energetic needs. Here, we review the recent findings on mitochondrial dynamics and mitophagy in differentiated neurons focusing on how the exceptional characteristics of neuronal populations in their morphology and bioenergetics needs make them quite different to other cells in controlling the intracellular turnover of these organelles." @default.
- W2123611234 created "2016-06-24" @default.
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- W2123611234 creator A5069598470 @default.
- W2123611234 creator A5081590385 @default.
- W2123611234 date "2014-01-01" @default.
- W2123611234 modified "2023-10-14" @default.
- W2123611234 title "Morphological and bioenergetic demands underlying the mitophagy in post-mitotic neurons: the pink–parkin pathway" @default.
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