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• W2123636721 abstract "To determine if elasticity in blood vessels is compromised in circadian clock-mutant mice (Bmal1-knockout [KO] and Per-triple KO) and if matrix metalloproteinases (MMPs) might confer these changes in compliance.High-resolution ultrasonography in vivo revealed impaired remodeling and increased pulse-wave velocity in the arteries of Bmal1-KO and Per-triple KO mice. In addition, compliance of remodeled arteries and naïve pressurized arterioles ex vivo from Bmal1-KO and Per-triple KO mice was reduced, consistent with stiffening of the vascular bed. The observed vascular stiffness was coincident with dysregulation of MMP-2 and MMP-9 in Bmal1-KO mice. Furthermore, inhibition of MMPs improved indexes of pathological remodeling in wild-type mice, but the effect was abolished in Bmal1-KO mice.Circadian clock dysfunction contributes to hardening of arteries, which may involve impaired control of the extracellular matrix composition." @default.
• W2123636721 created "2016-06-24" @default.
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• W2123636721 date "2010-12-01" @default.
• W2123636721 modified "2023-09-26" @default.
• W2123636721 title "Matrix Metalloproteinase 2 and 9 Dysfunction Underlie Vascular Stiffness in Circadian Clock Mutant Mice" @default.
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• W2123636721 doi "https://doi.org/10.1161/atvbaha.110.214379" @default.
• W2123636721 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2988111" @default.
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