FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123647512> ?p ?o ?g. }

• W2123647512 abstract "Abstract Cocaine inhibits high-affinity neurotransmitter uptake at the presynaptic nerve terminals to increase synaptic levels of dopamine, norepinephrine and serotonin^1^. This increase of synaptic dopamine may cause neurotoxicity^2,3^. At least two different mechanisms have been proposed for the development of dopamine-related neurotoxicity: 1) dopamine produces a free radical that may induce cell toxicity^2,3^ and 2) dopamine reduces glutamate transport at its presynaptic sites to increase synaptic levels of this amino acid^4^ and augments glutamate transmission by activating dopamine D1 receptors in different areas of the brain^5-7^. Increase in glutamatergic transmission mediated by the activation on N-methyl dextro-aspartate (NMDA) receptors has been shown to cause excitotoxicity and neuro-degeneration^8^. Others and we have reported protection against different psychotropic drug-induced neurotoxicity that may be achieved by prior or simultaneous administration of various pharmacological agents. For example, repeated treatment of rats with haloperidol induced neuronal damage that is ameliorated by prior administration of either GM1 ganglioside^9^ or the endogenous amino acid, taurine^10^. Similarly, chronic gestational cocaine exposure causes neurotoxicity that could be prevented by co-administration of clozapine^11^. To our knowledge, there is no information if chronic cocaine would enhance release of endogenous protective agents that may oppose the over activation of glutamatergic system. Here we show that repeated cocaine treatment increased synaptic levels of the neuroprotective amino acid taurine that opposes the excessive excitatory actions of the glutamatergic system in the rat brain. Thus, mammalian brain has an auto-protective mechanism to counter excitotoxicity and taurine or its synthetic derivative may be useful in the management and treatment of cocaine addiction and its neurotoxic effect." @default.
• W2123647512 created "2016-06-24" @default.
• W2123647512 creator A5005679928 @default.
• W2123647512 creator A5031496435 @default.
• W2123647512 creator A5037062026 @default.
• W2123647512 creator A5046588275 @default.
• W2123647512 creator A5067480003 @default.
• W2123647512 creator A5079571324 @default.
• W2123647512 date "2008-09-24" @default.
• W2123647512 modified "2023-09-24" @default.
• W2123647512 title "Chronic cocaine enhances release of neuroprotective amino acid taurine: a microdialysis study" @default.
• W2123647512 cites W1972599491 @default.
• W2123647512 cites W1982313467 @default.
• W2123647512 cites W1990156716 @default.
• W2123647512 cites W2011215391 @default.
• W2123647512 cites W2021099633 @default.
• W2123647512 cites W2027940350 @default.
• W2123647512 cites W2030957166 @default.
• W2123647512 cites W2055354313 @default.
• W2123647512 cites W2056839574 @default.
• W2123647512 cites W2057892973 @default.
• W2123647512 cites W2066354419 @default.
• W2123647512 cites W2084769710 @default.
• W2123647512 cites W2097801108 @default.
• W2123647512 cites W2116401151 @default.
• W2123647512 cites W2123946759 @default.
• W2123647512 cites W2130634332 @default.
• W2123647512 cites W2138856840 @default.
• W2123647512 cites W2141621911 @default.
• W2123647512 cites W2163815564 @default.
• W2123647512 cites W2163844136 @default.
• W2123647512 cites W2165531015 @default.
• W2123647512 cites W2171098630 @default.
• W2123647512 cites W350539777 @default.
• W2123647512 cites W62603772 @default.
• W2123647512 doi "https://doi.org/10.1038/npre.2008.2319.1" @default.
• W2123647512 hasPublicationYear "2008" @default.
• W2123647512 type Work @default.
• W2123647512 sameAs 2123647512 @default.
• W2123647512 citedByCount "0" @default.
• W2123647512 crossrefType "journal-article" @default.
• W2123647512 hasAuthorship W2123647512A5005679928 @default.
• W2123647512 hasAuthorship W2123647512A5031496435 @default.
• W2123647512 hasAuthorship W2123647512A5037062026 @default.
• W2123647512 hasAuthorship W2123647512A5046588275 @default.
• W2123647512 hasAuthorship W2123647512A5067480003 @default.
• W2123647512 hasAuthorship W2123647512A5079571324 @default.
• W2123647512 hasBestOaLocation W21236475121 @default.
• W2123647512 hasConcept C169760540 @default.
• W2123647512 hasConcept C170493617 @default.
• W2123647512 hasConcept C178790620 @default.
• W2123647512 hasConcept C185592680 @default.
• W2123647512 hasConcept C200170125 @default.
• W2123647512 hasConcept C25498285 @default.
• W2123647512 hasConcept C2776219046 @default.
• W2123647512 hasConcept C2779491297 @default.
• W2123647512 hasConcept C2779701627 @default.
• W2123647512 hasConcept C2780648746 @default.
• W2123647512 hasConcept C2781012912 @default.
• W2123647512 hasConcept C29730261 @default.
• W2123647512 hasConcept C513476851 @default.
• W2123647512 hasConcept C515207424 @default.
• W2123647512 hasConcept C55493867 @default.
• W2123647512 hasConcept C61174792 @default.
• W2123647512 hasConcept C67018056 @default.
• W2123647512 hasConcept C86803240 @default.
• W2123647512 hasConcept C98274493 @default.
• W2123647512 hasConceptScore W2123647512C169760540 @default.
• W2123647512 hasConceptScore W2123647512C170493617 @default.
• W2123647512 hasConceptScore W2123647512C178790620 @default.
• W2123647512 hasConceptScore W2123647512C185592680 @default.
• W2123647512 hasConceptScore W2123647512C200170125 @default.
• W2123647512 hasConceptScore W2123647512C25498285 @default.
• W2123647512 hasConceptScore W2123647512C2776219046 @default.
• W2123647512 hasConceptScore W2123647512C2779491297 @default.
• W2123647512 hasConceptScore W2123647512C2779701627 @default.
• W2123647512 hasConceptScore W2123647512C2780648746 @default.
• W2123647512 hasConceptScore W2123647512C2781012912 @default.
• W2123647512 hasConceptScore W2123647512C29730261 @default.
• W2123647512 hasConceptScore W2123647512C513476851 @default.
• W2123647512 hasConceptScore W2123647512C515207424 @default.
• W2123647512 hasConceptScore W2123647512C55493867 @default.
• W2123647512 hasConceptScore W2123647512C61174792 @default.
• W2123647512 hasConceptScore W2123647512C67018056 @default.
• W2123647512 hasConceptScore W2123647512C86803240 @default.
• W2123647512 hasConceptScore W2123647512C98274493 @default.
• W2123647512 hasLocation W21236475121 @default.
• W2123647512 hasOpenAccess W2123647512 @default.
• W2123647512 hasPrimaryLocation W21236475121 @default.
• W2123647512 hasRelatedWork W1987380889 @default.
• W2123647512 hasRelatedWork W2010503936 @default.
• W2123647512 hasRelatedWork W2025044757 @default.
• W2123647512 hasRelatedWork W2044433533 @default.
• W2123647512 hasRelatedWork W2079269749 @default.
• W2123647512 hasRelatedWork W2123647512 @default.
• W2123647512 hasRelatedWork W2253866587 @default.
• W2123647512 hasRelatedWork W2413242638 @default.
• W2123647512 hasRelatedWork W2465937456 @default.
• W2123647512 hasRelatedWork W2489713514 @default.
• W2123647512 isParatext "false" @default.

• next