FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123669968> ?p ?o ?g. }

• W2123669968 endingPage "e3236" @default.
• W2123669968 startingPage "e3236" @default.
• W2123669968 abstract "An 81 year old woman with a long term, indwelling urinary catheter is admitted with fever and hypotension thought to be due to septicaemia secondary to urinary tract infection. She is treated empirically with intravenous cefotaxime and gentamicin, but her condition deteriorates over 24 hours, with increasing hypotension and continuing fever. For broader spectrum coverage, her empirical antibiotic treatment is changed to intravenous meropenem. The next day, urine and blood cultures grow an Escherichia coli producing an extended spectrum β lactamase (ESBL), conferring resistance to cefotaxime and gentamicin but not to meropenem. The meropenem is continued for seven days, with clinical and bacteriological resolution of the patient’s infection.Carbapenems are β lactam antibiotics, as are penicillins and cephalosporins, but differ from these other classes in their exact chemical structure. Carbapenem use has increased as a result of the rising resistance to cephalosporin antibiotics in Enterobacteriaceae ( Escherichia coli , Klebsiella , Enterobacter , and related genera). This cephalosporin resistance is largely due to the spread of extended spectrum β lactamases (ESBLs), which hydrolyse cephalosporins.1 ESBL producers are associated with poor clinical outcomes in severe infections: a meta-analysis found that bacteraemias caused by bacteria with these enzymes had 1.85-fold increased mortality (95% confidence interval 1.39 to 2.47, P<0.001), reflecting extended delays before effective therapy was initiated.2 ESBLs now occur in 10–12% of E coli from bacteraemias in the UK3 and in 50–80% of those in India and China, with many ESBL producing strains also resistant to quinolones and aminoglycosides.4Carbapenems are the sole β lactam antibiotics with proven efficacy in severe infections due to ESBL producing bacteria: most Enterobacteriaceae strains with ESBLs in the UK are resistant to the β lactamase inhibitor combinations of amoxicillin-clavulanate and piperacillin-tazobactam—not because the ESBLs evade inhibition but because ESBL producers often also …" @default.
• W2123669968 created "2016-06-24" @default.
• W2123669968 creator A5026816951 @default.
• W2123669968 creator A5072423246 @default.
• W2123669968 date "2012-05-31" @default.
• W2123669968 modified "2023-10-17" @default.
• W2123669968 title "Carbapenem antibiotics for serious infections" @default.
• W2123669968 cites W1809028167 @default.
• W2123669968 cites W1964922695 @default.
• W2123669968 cites W1972079818 @default.
• W2123669968 cites W1984472487 @default.
• W2123669968 cites W1986583614 @default.
• W2123669968 cites W1990154334 @default.
• W2123669968 cites W2006675624 @default.
• W2123669968 cites W2014854825 @default.
• W2123669968 cites W2019460984 @default.
• W2123669968 cites W2029755389 @default.
• W2123669968 cites W2095484440 @default.
• W2123669968 cites W2103780797 @default.
• W2123669968 cites W2104265834 @default.
• W2123669968 cites W2118650984 @default.
• W2123669968 cites W2119452025 @default.
• W2123669968 cites W2129015046 @default.
• W2123669968 cites W2132086274 @default.
• W2123669968 cites W2133727913 @default.
• W2123669968 cites W2138069373 @default.
• W2123669968 cites W2141674598 @default.
• W2123669968 cites W2143982063 @default.
• W2123669968 cites W2146002077 @default.
• W2123669968 cites W2152899131 @default.
• W2123669968 cites W2154007902 @default.
• W2123669968 cites W2154556219 @default.
• W2123669968 cites W2160197952 @default.
• W2123669968 cites W2161281588 @default.
• W2123669968 cites W2161924323 @default.
• W2123669968 cites W2167638718 @default.
• W2123669968 cites W2167963429 @default.
• W2123669968 doi "https://doi.org/10.1136/bmj.e3236" @default.
• W2123669968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22654063" @default.
• W2123669968 hasPublicationYear "2012" @default.
• W2123669968 type Work @default.
• W2123669968 sameAs 2123669968 @default.
• W2123669968 citedByCount "90" @default.
• W2123669968 countsByYear W21236699682012 @default.
• W2123669968 countsByYear W21236699682013 @default.
• W2123669968 countsByYear W21236699682014 @default.
• W2123669968 countsByYear W21236699682015 @default.
• W2123669968 countsByYear W21236699682016 @default.
• W2123669968 countsByYear W21236699682017 @default.
• W2123669968 countsByYear W21236699682018 @default.
• W2123669968 countsByYear W21236699682019 @default.
• W2123669968 countsByYear W21236699682020 @default.
• W2123669968 countsByYear W21236699682021 @default.
• W2123669968 countsByYear W21236699682022 @default.
• W2123669968 countsByYear W21236699682023 @default.
• W2123669968 crossrefType "journal-article" @default.
• W2123669968 hasAuthorship W2123669968A5026816951 @default.
• W2123669968 hasAuthorship W2123669968A5072423246 @default.
• W2123669968 hasConcept C177713679 @default.
• W2123669968 hasConcept C2776685102 @default.
• W2123669968 hasConcept C501593827 @default.
• W2123669968 hasConcept C71924100 @default.
• W2123669968 hasConcept C86803240 @default.
• W2123669968 hasConcept C89423630 @default.
• W2123669968 hasConceptScore W2123669968C177713679 @default.
• W2123669968 hasConceptScore W2123669968C2776685102 @default.
• W2123669968 hasConceptScore W2123669968C501593827 @default.
• W2123669968 hasConceptScore W2123669968C71924100 @default.
• W2123669968 hasConceptScore W2123669968C86803240 @default.
• W2123669968 hasConceptScore W2123669968C89423630 @default.
• W2123669968 hasIssue "may31 1" @default.
• W2123669968 hasLocation W21236699681 @default.
• W2123669968 hasLocation W21236699682 @default.
• W2123669968 hasOpenAccess W2123669968 @default.
• W2123669968 hasPrimaryLocation W21236699681 @default.
• W2123669968 hasRelatedWork W1506200166 @default.
• W2123669968 hasRelatedWork W1995515455 @default.
• W2123669968 hasRelatedWork W2048182022 @default.
• W2123669968 hasRelatedWork W2080531066 @default.
• W2123669968 hasRelatedWork W2604872355 @default.
• W2123669968 hasRelatedWork W2748952813 @default.
• W2123669968 hasRelatedWork W2899084033 @default.
• W2123669968 hasRelatedWork W3031052312 @default.
• W2123669968 hasRelatedWork W3032375762 @default.
• W2123669968 hasRelatedWork W3108674512 @default.
• W2123669968 hasVolume "344" @default.
• W2123669968 isParatext "false" @default.
• W2123669968 isRetracted "false" @default.
• W2123669968 magId "2123669968" @default.
• W2123669968 workType "article" @default.