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- W2123702933 abstract "The influence of nucleotide excision repair (NER), the principal in vivo repair system for DNA damages, was investigated in Escherichia coli with uvrA, uvrB and uvrAuvrB mutants with the triplet repeat sequences (TRS) involved in myotonic dystrophy, the fragile X syndrome and Friedreich's ataxia. (CTG•CAG)175 was more stable when the (CTG) strand was transcribed than when the (CAG) strand was transcribed in the alternate orientation. A lack of the UvrA protein dramatically increases the instability of this TRS in vivo as compared with the stability of the same sequence in uvrB mutant, which produces an intact UvrA protein. We propose that transcription transiently dissociates the triplet repeat complementary strands enabling the nontranscribed strand to fold into a hairpin conformation which is then sufficiently stable that replication bypasses the hairpin to give large deletions. If the TRS was not transcribed, fewer deletions were observed. Alternatively, in the uvrA− mutant, the hairpins existing on the lagging strand will suffer bypass DNA synthesis to generate deleted molecules. Hence, NER, functionally similar in both prokaryotes and eukaryotes, is an important factor in the genetic instabilities of long transcribed TRS implicated in human hereditary neurological diseases." @default.
- W2123702933 created "2016-06-24" @default.
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- W2123702933 date "1999-01-01" @default.
- W2123702933 modified "2023-09-24" @default.
- W2123702933 title "Nucleotide excision repair affects the stability of long transcribed (CTG*CAG) tracts in an orientation-dependent manner in Escherichia coli" @default.
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- W2123702933 cites W1651950734 @default.
- W2123702933 cites W1970585122 @default.
- W2123702933 cites W1981112371 @default.
- W2123702933 cites W1983385891 @default.
- W2123702933 cites W1984865535 @default.
- W2123702933 cites W1987246047 @default.
- W2123702933 cites W1994272135 @default.
- W2123702933 cites W1995021789 @default.
- W2123702933 cites W1998003151 @default.
- W2123702933 cites W2000856801 @default.
- W2123702933 cites W2002093858 @default.
- W2123702933 cites W2003275808 @default.
- W2123702933 cites W2005960028 @default.
- W2123702933 cites W2007368142 @default.
- W2123702933 cites W2009230970 @default.
- W2123702933 cites W2012888840 @default.
- W2123702933 cites W2015313250 @default.
- W2123702933 cites W2015324688 @default.
- W2123702933 cites W2017237069 @default.
- W2123702933 cites W2019043328 @default.
- W2123702933 cites W2021498593 @default.
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- W2123702933 cites W2025790565 @default.
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- W2123702933 cites W2030784849 @default.
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- W2123702933 doi "https://doi.org/10.1093/nar/27.2.616" @default.
- W2123702933 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/148223" @default.
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