Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123704198> ?p ?o ?g. }
- W2123704198 endingPage "3006" @default.
- W2123704198 startingPage "2977" @default.
- W2123704198 abstract "The outbreak of West Nile virus (WNV) in 1999 in the USA, and its continued spread throughout the Americas, parts of Europe, the Middle East and Africa, underscored the need for WNV antiviral development. Here, we review the current status of WNV drug discovery. A number of approaches have been used to search for inhibitors of WNV, including viral infection-based screening, enzyme-based screening, structure-based virtual screening, structure-based rationale design, and antibody-based therapy. These efforts have yielded inhibitors of viral or cellular factors that are critical for viral replication. For small molecule inhibitors, no promising preclinical candidate has been developed; most of the inhibitors could not even be advanced to the stage of hit-to-lead optimization due to their poor drug-like properties. However, several inhibitors developed for related members of the family Flaviviridae, such as dengue virus and hepatitis C virus, exhibited cross-inhibition of WNV, suggesting the possibility to re-purpose these antivirals for WNV treatment. Most promisingly, therapeutic antibodies have shown excellent efficacy in mouse model; one of such antibodies has been advanced into clinical trial. The knowledge accumulated during the past fifteen years has provided better rationale for the ongoing WNV and other flavivirus antiviral development." @default.
- W2123704198 created "2016-06-24" @default.
- W2123704198 creator A5022429604 @default.
- W2123704198 creator A5063531107 @default.
- W2123704198 date "2013-12-03" @default.
- W2123704198 modified "2023-09-27" @default.
- W2123704198 title "West Nile Virus Drug Discovery" @default.
- W2123704198 cites W1508093164 @default.
- W2123704198 cites W1570836961 @default.
- W2123704198 cites W1964529072 @default.
- W2123704198 cites W1964571618 @default.
- W2123704198 cites W1965693775 @default.
- W2123704198 cites W1965936780 @default.
- W2123704198 cites W1966647726 @default.
- W2123704198 cites W1968089596 @default.
- W2123704198 cites W1968353490 @default.
- W2123704198 cites W1971194665 @default.
- W2123704198 cites W1971245203 @default.
- W2123704198 cites W1971368161 @default.
- W2123704198 cites W1975462182 @default.
- W2123704198 cites W1976257768 @default.
- W2123704198 cites W1979427503 @default.
- W2123704198 cites W1981910825 @default.
- W2123704198 cites W1982697237 @default.
- W2123704198 cites W1983807744 @default.
- W2123704198 cites W1983863966 @default.
- W2123704198 cites W1985946670 @default.
- W2123704198 cites W1989831705 @default.
- W2123704198 cites W1990482989 @default.
- W2123704198 cites W1990701251 @default.
- W2123704198 cites W1991249533 @default.
- W2123704198 cites W1991555520 @default.
- W2123704198 cites W1995667567 @default.
- W2123704198 cites W1999732999 @default.
- W2123704198 cites W2001296775 @default.
- W2123704198 cites W2001856601 @default.
- W2123704198 cites W2002545308 @default.
- W2123704198 cites W2004274451 @default.
- W2123704198 cites W2004680936 @default.
- W2123704198 cites W2004807281 @default.
- W2123704198 cites W2005510346 @default.
- W2123704198 cites W2008052842 @default.
- W2123704198 cites W2011500811 @default.
- W2123704198 cites W2012060186 @default.
- W2123704198 cites W2012415080 @default.
- W2123704198 cites W2014990343 @default.
- W2123704198 cites W2020237669 @default.
- W2123704198 cites W2020597234 @default.
- W2123704198 cites W2021928505 @default.
- W2123704198 cites W2024248637 @default.
- W2123704198 cites W2024970900 @default.
- W2123704198 cites W2025638022 @default.
- W2123704198 cites W2025932784 @default.
- W2123704198 cites W2025946769 @default.
- W2123704198 cites W2028064829 @default.
- W2123704198 cites W2028198504 @default.
- W2123704198 cites W2029052029 @default.
- W2123704198 cites W2029705901 @default.
- W2123704198 cites W2030949148 @default.
- W2123704198 cites W2033202588 @default.
- W2123704198 cites W2033319184 @default.
- W2123704198 cites W2035062023 @default.
- W2123704198 cites W2035062239 @default.
- W2123704198 cites W2037775614 @default.
- W2123704198 cites W2041818331 @default.
- W2123704198 cites W2042390882 @default.
- W2123704198 cites W2042598433 @default.
- W2123704198 cites W2043189472 @default.
- W2123704198 cites W2044749643 @default.
- W2123704198 cites W2045740959 @default.
- W2123704198 cites W2046174017 @default.
- W2123704198 cites W2046311880 @default.
- W2123704198 cites W2047435891 @default.
- W2123704198 cites W2048699176 @default.
- W2123704198 cites W2049285992 @default.
- W2123704198 cites W2050843600 @default.
- W2123704198 cites W2053476322 @default.
- W2123704198 cites W2054056331 @default.
- W2123704198 cites W2055034642 @default.
- W2123704198 cites W2056700536 @default.
- W2123704198 cites W2057062198 @default.
- W2123704198 cites W2058273760 @default.
- W2123704198 cites W2061167896 @default.
- W2123704198 cites W2066528340 @default.
- W2123704198 cites W2067551878 @default.
- W2123704198 cites W2068167401 @default.
- W2123704198 cites W2068185438 @default.
- W2123704198 cites W2068264550 @default.
- W2123704198 cites W2071218237 @default.
- W2123704198 cites W2072304539 @default.
- W2123704198 cites W2072603184 @default.
- W2123704198 cites W2073727854 @default.
- W2123704198 cites W2077381372 @default.
- W2123704198 cites W2078798933 @default.
- W2123704198 cites W2080725002 @default.
- W2123704198 cites W2080900122 @default.
- W2123704198 cites W2084549251 @default.
- W2123704198 cites W2085938990 @default.