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• W2123710102 abstract "In patients with carotid stenosis or occlusion, cerebral blood could be supplied through collateral pathways to improve regional blood flow and protect against ischemic events. The contribution of collaterals from the ICA can be assessed by depiction of vascular perfusion territories with ASL. However, so far there is no method available to evaluate the collateral perfusion territory from the ECA in MR imaging. In this study, we present a new labeling scheme based on VE-ASL to quantitatively assess the perfusion territory of the ECA.A new labeling approach with a Hadamard encoding scheme was developed to label major arteries, especially the ECA. Twelve healthy subjects with normal cerebrovascular anatomy were examined to demonstrate their perfusion territories. Eight patients with carotid artery stenosis or occlusion were assessed before and after surgery to show changes of their collateral blood supply.The proposed method enables assessment of the perfusion territories of the ECA. Good agreement was found between the vascular territories and normal cerebrovascular anatomy in healthy subjects. For the patients with carotid stenosis or occlusion, our noninvasive results provided information on collateral flow comparable with that from DSA. Their collateral flows from the ECA, moreover, could be quantitatively estimated pre- and postoperatively.The modified approach has been validated by the consistency of collateral perfusion territories with cerebrovascular anatomy, and quantitative assessment of collaterals proved useful for assisting in evaluating therapeutic interventions." @default.
• W2123710102 created "2016-06-24" @default.
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• W2123710102 date "2012-02-16" @default.
• W2123710102 modified "2023-09-27" @default.
• W2123710102 title "Quantitative Assessment of External Carotid Artery Territory Supply with Modified Vessel-Encoded Arterial Spin-Labeling" @default.
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• W2123710102 doi "https://doi.org/10.3174/ajnr.a2978" @default.
• W2123710102 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7965524" @default.
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• W2123710102 hasPublicationYear "2012" @default.
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