FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123725105> ?p ?o ?g. }

• W2123725105 endingPage "E292" @default.
• W2123725105 startingPage "E282" @default.
• W2123725105 abstract "Obesity continues to be a global health problem, and thus it is imperative that new pathways regulating energy balance be identified. Recently, it was reported: (Hayashi K, Cao T, Passmore H, Jourdan-Le Saux C, Fogelgren B, Khan S, Hornstra I, Kim Y, Hayashi M, Csiszar K. J Invest Dermatol 123: 864–871, 2004) that mice carrying a missense mutation in myelin protein zero-like 3 ( Mpzl3 rc ) have reduced body weight. To determine how Mpzl3 controls energy balance in vivo, we generated mice deficient in myelin protein zero-like 3 ( Mpzl3-KO). Interestingly, KO mice were hyperphagic yet had reduced body weight and fat mass. Moreover, KO mice were highly resistant to body weight and fat mass gain after exposure to a high-fat, energy-dense diet. These effects on body weight and adiposity were driven, in part, by a pronounced increase in whole body energy expenditure levels in KO mice. KO mice also had reduced blood glucose levels during an intraperitoneal glucose challenge and significant reductions in circulating insulin levels suggesting an increase in insulin sensitivity. In addition, there was an overall increase in oxidative capacity and contractile force in skeletal muscle isolated from KO mice. Hepatic triglyceride levels were reduced by 92% in livers of KO mice, in part due to a reduction in de novo lipid synthesis. Interestingly, Mpzl3 mRNA expression in liver was increased in diet-induced obese mice. Moreover, KO mice exhibited an increase in insulin-stimulated Akt signaling in the liver, further demonstrating that Mpzl3 can regulate insulin sensitivity in this tissue. We have determined that Mpzl3 has a novel physiological role in controlling body weight regulation, energy expenditure, glycemic control, and hepatic triglyceride synthesis in mice." @default.
• W2123725105 created "2016-06-24" @default.
• W2123725105 creator A5003697807 @default.
• W2123725105 creator A5011878357 @default.
• W2123725105 creator A5011961229 @default.
• W2123725105 creator A5021116004 @default.
• W2123725105 creator A5023150353 @default.
• W2123725105 creator A5024018943 @default.
• W2123725105 creator A5030517201 @default.
• W2123725105 creator A5037353908 @default.
• W2123725105 creator A5054260296 @default.
• W2123725105 creator A5060055772 @default.
• W2123725105 creator A5065004418 @default.
• W2123725105 creator A5075934968 @default.
• W2123725105 date "2013-07-15" @default.
• W2123725105 modified "2023-09-27" @default.
• W2123725105 title "Genetic ablation of myelin protein zero-like 3 in mice increases energy expenditure, improves glycemic control, and reduces hepatic lipid synthesis" @default.
• W2123725105 cites W1517312396 @default.
• W2123725105 cites W1967315314 @default.
• W2123725105 cites W1969734540 @default.
• W2123725105 cites W1971082641 @default.
• W2123725105 cites W1973304265 @default.
• W2123725105 cites W1980773492 @default.
• W2123725105 cites W1986731704 @default.
• W2123725105 cites W1992326632 @default.
• W2123725105 cites W1995375315 @default.
• W2123725105 cites W1997404862 @default.
• W2123725105 cites W1998414295 @default.
• W2123725105 cites W2002447427 @default.
• W2123725105 cites W2008422410 @default.
• W2123725105 cites W2008749530 @default.
• W2123725105 cites W2015454275 @default.
• W2123725105 cites W2023989509 @default.
• W2123725105 cites W2027753197 @default.
• W2123725105 cites W2031611592 @default.
• W2123725105 cites W2035340480 @default.
• W2123725105 cites W2046859247 @default.
• W2123725105 cites W2048450951 @default.
• W2123725105 cites W2048667936 @default.
• W2123725105 cites W2050558733 @default.
• W2123725105 cites W2056598213 @default.
• W2123725105 cites W2061278204 @default.
• W2123725105 cites W2064695336 @default.
• W2123725105 cites W2082936063 @default.
• W2123725105 cites W2086501334 @default.
• W2123725105 cites W2093429971 @default.
• W2123725105 cites W2109990111 @default.
• W2123725105 cites W2114953965 @default.
• W2123725105 cites W2119441851 @default.
• W2123725105 cites W2121161073 @default.
• W2123725105 cites W2122300870 @default.
• W2123725105 cites W2124711253 @default.
• W2123725105 cites W2125118264 @default.
• W2123725105 cites W2129050532 @default.
• W2123725105 cites W2131536322 @default.
• W2123725105 cites W2137283361 @default.
• W2123725105 cites W2141223773 @default.
• W2123725105 cites W2146754677 @default.
• W2123725105 cites W2158684589 @default.
• W2123725105 cites W2170293889 @default.
• W2123725105 cites W4251371932 @default.
• W2123725105 cites W2136031976 @default.
• W2123725105 doi "https://doi.org/10.1152/ajpendo.00228.2013" @default.
• W2123725105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23715724" @default.
• W2123725105 hasPublicationYear "2013" @default.
• W2123725105 type Work @default.
• W2123725105 sameAs 2123725105 @default.
• W2123725105 citedByCount "14" @default.
• W2123725105 countsByYear W21237251052014 @default.
• W2123725105 countsByYear W21237251052015 @default.
• W2123725105 countsByYear W21237251052016 @default.
• W2123725105 countsByYear W21237251052017 @default.
• W2123725105 countsByYear W21237251052020 @default.
• W2123725105 countsByYear W21237251052021 @default.
• W2123725105 countsByYear W21237251052022 @default.
• W2123725105 countsByYear W21237251052023 @default.
• W2123725105 crossrefType "journal-article" @default.
• W2123725105 hasAuthorship W2123725105A5003697807 @default.
• W2123725105 hasAuthorship W2123725105A5011878357 @default.
• W2123725105 hasAuthorship W2123725105A5011961229 @default.
• W2123725105 hasAuthorship W2123725105A5021116004 @default.
• W2123725105 hasAuthorship W2123725105A5023150353 @default.
• W2123725105 hasAuthorship W2123725105A5024018943 @default.
• W2123725105 hasAuthorship W2123725105A5030517201 @default.
• W2123725105 hasAuthorship W2123725105A5037353908 @default.
• W2123725105 hasAuthorship W2123725105A5054260296 @default.
• W2123725105 hasAuthorship W2123725105A5060055772 @default.
• W2123725105 hasAuthorship W2123725105A5065004418 @default.
• W2123725105 hasAuthorship W2123725105A5075934968 @default.
• W2123725105 hasConcept C126322002 @default.
• W2123725105 hasConcept C134018914 @default.
• W2123725105 hasConcept C185592680 @default.
• W2123725105 hasConcept C2779306644 @default.
• W2123725105 hasConcept C2780473172 @default.
• W2123725105 hasConcept C71924100 @default.
• W2123725105 hasConcept C86803240 @default.
• W2123725105 hasConceptScore W2123725105C126322002 @default.
• W2123725105 hasConceptScore W2123725105C134018914 @default.

• next