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- W2123735541 abstract "Simple alkylating agents form an interesting class of chemical carcinogens whose interaction with DNA is relatively well understood (1–7). These carcinogens include agents such as alkyl alkanesulfonates, alkylnitrosamides, alkylnitrosoguanidines, and monoalkyltriazines that are direct acting and the chemically-stable nitrosamines, dialkylhydrazines, and dialkyltriazines that require enzymatic activation to generate the alkylating species. The major adducts formed by these agents on reaction with DNA in target and nontarget tissues have been quantitated and their persistence with time measured (1,2,5,6). These studies have suggested that certain adducts are more likely to be responsible for the initiation of tumors than others; particular emphasis has been placed on the potential role of O 6-alkylguanine. O 6-Alkylguanine is known to miscode in nucleic acid synthesis and to lead to mutations. Furthermore, its rate of removal from DNA. differs from tissue to tissue, and the persistence correlates with sensitivity to tumor initiation (1,2,5). These results underline the significant role that DNA repair may play in preventing a carcinogenesis by alkylating agents. Other alkylated bases may also have the potential to initiate tumors, but the rapid removal would minimize their effect." @default.
- W2123735541 created "2016-06-24" @default.
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- W2123735541 date "1983-01-01" @default.
- W2123735541 modified "2023-09-25" @default.
- W2123735541 title "Repair of Alkylated DNA by Cell Extracts from Various Organs and Species" @default.
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- W2123735541 doi "https://doi.org/10.1007/978-1-4684-4400-1_29" @default.
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