Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123744988> ?p ?o ?g. }
- W2123744988 endingPage "2237" @default.
- W2123744988 startingPage "2223" @default.
- W2123744988 abstract "Cancer commonly occurs in the elderly and immunotherapy (IT) is being increasingly applied to this population. However, the majority of preclinical mouse tumor models assessing potential efficacy and toxicities of therapeutics use young mice. We assessed the impact of age on responses to systemic immune stimulation. In contrast to young mice, systemic cancer IT regimens or LPS given to aged mice resulted in rapid and lethal toxicities affecting multiple organs correlating with heightened proinflammatory cytokines systemically and within the parenchymal tissues. This inflammatory response and increased morbidity with age was independent of T cells or NK cells. However, prior in vivo depletion of macrophages in aged mice resulted in lesser cytokine levels, increased survival, and decreased liver histopathology. Furthermore, macrophages from aged mice and normal human elderly volunteers displayed heightened TNF and IL-6 production upon in vitro stimulation. Treatment of both TNF knockout mice and in vivo TNF blockade in aged mice resulted in significant increases in survival and lessened pathology. Importantly, TNF blockade in tumor-bearing, aged mice receiving IT displayed significant anti-tumor effects. These data demonstrate the critical role of macrophages in the age-associated hyper-inflammatory cytokine responses to systemic immunostimulation and underscore the importance of performing preclinical assessments in aged mice." @default.
- W2123744988 created "2016-06-24" @default.
- W2123744988 creator A5002583473 @default.
- W2123744988 creator A5004928669 @default.
- W2123744988 creator A5010903477 @default.
- W2123744988 creator A5020913460 @default.
- W2123744988 creator A5027145036 @default.
- W2123744988 creator A5030729248 @default.
- W2123744988 creator A5031507979 @default.
- W2123744988 creator A5035085941 @default.
- W2123744988 creator A5039707350 @default.
- W2123744988 creator A5042070203 @default.
- W2123744988 creator A5048109671 @default.
- W2123744988 creator A5048196698 @default.
- W2123744988 creator A5053113756 @default.
- W2123744988 creator A5057986934 @default.
- W2123744988 creator A5058268746 @default.
- W2123744988 creator A5065634805 @default.
- W2123744988 creator A5079900226 @default.
- W2123744988 creator A5090896111 @default.
- W2123744988 creator A5091594218 @default.
- W2123744988 date "2013-09-30" @default.
- W2123744988 modified "2023-10-12" @default.
- W2123744988 title "Aging predisposes to acute inflammatory induced pathology after tumor immunotherapy" @default.
- W2123744988 cites W1630570293 @default.
- W2123744988 cites W1859203717 @default.
- W2123744988 cites W1963991141 @default.
- W2123744988 cites W1969946019 @default.
- W2123744988 cites W1974508346 @default.
- W2123744988 cites W1979107859 @default.
- W2123744988 cites W1981274829 @default.
- W2123744988 cites W1994316830 @default.
- W2123744988 cites W1998139299 @default.
- W2123744988 cites W1999081675 @default.
- W2123744988 cites W2001627013 @default.
- W2123744988 cites W2001700978 @default.
- W2123744988 cites W2005822229 @default.
- W2123744988 cites W2025421728 @default.
- W2123744988 cites W2032386695 @default.
- W2123744988 cites W2034392291 @default.
- W2123744988 cites W2036632702 @default.
- W2123744988 cites W2041227327 @default.
- W2123744988 cites W2045074773 @default.
- W2123744988 cites W2052554412 @default.
- W2123744988 cites W2054167475 @default.
- W2123744988 cites W2057123987 @default.
- W2123744988 cites W2061294496 @default.
- W2123744988 cites W2068234766 @default.
- W2123744988 cites W2072857434 @default.
- W2123744988 cites W2075393281 @default.
- W2123744988 cites W2080999576 @default.
- W2123744988 cites W2082402714 @default.
- W2123744988 cites W2089643849 @default.
- W2123744988 cites W2090165963 @default.
- W2123744988 cites W2095013915 @default.
- W2123744988 cites W2095138364 @default.
- W2123744988 cites W2098432330 @default.
- W2123744988 cites W2109653150 @default.
- W2123744988 cites W2111491084 @default.
- W2123744988 cites W2112069616 @default.
- W2123744988 cites W2112853593 @default.
- W2123744988 cites W2117867456 @default.
- W2123744988 cites W2125170576 @default.
- W2123744988 cites W2136722399 @default.
- W2123744988 cites W2137114965 @default.
- W2123744988 cites W2141258726 @default.
- W2123744988 cites W2141989396 @default.
- W2123744988 cites W2147550589 @default.
- W2123744988 cites W2148703658 @default.
- W2123744988 cites W2148834609 @default.
- W2123744988 cites W2153161557 @default.
- W2123744988 cites W2156222101 @default.
- W2123744988 cites W2162428378 @default.
- W2123744988 cites W2163721979 @default.
- W2123744988 cites W2166802777 @default.
- W2123744988 cites W2277878249 @default.
- W2123744988 cites W2395121051 @default.
- W2123744988 cites W4244761347 @default.
- W2123744988 cites W4250497858 @default.
- W2123744988 doi "https://doi.org/10.1084/jem.20131219" @default.
- W2123744988 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3804937" @default.
- W2123744988 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24081947" @default.
- W2123744988 hasPublicationYear "2013" @default.
- W2123744988 type Work @default.
- W2123744988 sameAs 2123744988 @default.
- W2123744988 citedByCount "116" @default.
- W2123744988 countsByYear W21237449882013 @default.
- W2123744988 countsByYear W21237449882014 @default.
- W2123744988 countsByYear W21237449882015 @default.
- W2123744988 countsByYear W21237449882016 @default.
- W2123744988 countsByYear W21237449882017 @default.
- W2123744988 countsByYear W21237449882018 @default.
- W2123744988 countsByYear W21237449882019 @default.
- W2123744988 countsByYear W21237449882020 @default.
- W2123744988 countsByYear W21237449882021 @default.
- W2123744988 countsByYear W21237449882022 @default.
- W2123744988 countsByYear W21237449882023 @default.
- W2123744988 crossrefType "journal-article" @default.