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- W2123745142 abstract "Poorly soluble particles such as TiO2, carbon black, and diesel exhaust particles have been evaluated for their genotoxicity using both in vitro and in vivo assays, since inhalation of these compounds by rats at high concentrations has been found to lead to tumor formation. Two principle modes of genotoxic action can be considered for particles, referred to as primary and secondary genotoxicity. Primary genotoxicity is defined as genetic damage elicited by particles in the absence of pulmonary inflammation, whereas secondary genotoxicity implies a pathway of genetic damage resulting from the oxidative DNA attack by reactive oxygen/nitrogen species (ROS/RNS), generated during particle-elicited inflammation. Conceptually, primary genotoxicity might operate via various mechanisms, such as the actions of ROS (e.g., as generated from reactive particle surfaces), or DNA-adduct formation by reactive metabolites of particle-associated organic compounds (e.g., polycyclic aromatic hydrocarbons). Currently available literature data, however, merely indicate that the tumorigenesis of poorly soluble particles involves a mechanism of secondary genotoxicity. However, further research is urgently required, since (1) causality between pulmonary inflammation and genotoxicity has not yet been established, and (2) effects of inflammation on fundamental DNA damage responses that orchestrate mutagenesis and carcinogenic outcome,that is, cell cycle arrest, DNA repair, proliferation, and apoptosis, are currently poorly understood." @default.
- W2123745142 created "2016-06-24" @default.
- W2123745142 creator A5014346215 @default.
- W2123745142 creator A5042016316 @default.
- W2123745142 date "2007-01-01" @default.
- W2123745142 modified "2023-09-30" @default.
- W2123745142 title "Genotoxicity of Poorly Soluble Particles" @default.
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- W2123745142 cites W1963712961 @default.
- W2123745142 cites W1964786557 @default.
- W2123745142 cites W1965243648 @default.
- W2123745142 cites W1967123346 @default.
- W2123745142 cites W1971472148 @default.
- W2123745142 cites W1974691766 @default.
- W2123745142 cites W1991700059 @default.
- W2123745142 cites W2006531657 @default.
- W2123745142 cites W2011912935 @default.
- W2123745142 cites W2012595040 @default.
- W2123745142 cites W2013112981 @default.
- W2123745142 cites W2020942959 @default.
- W2123745142 cites W2022014262 @default.
- W2123745142 cites W2028077246 @default.
- W2123745142 cites W2029243559 @default.
- W2123745142 cites W2036986058 @default.
- W2123745142 cites W2037531780 @default.
- W2123745142 cites W2043787490 @default.
- W2123745142 cites W2043875502 @default.
- W2123745142 cites W2044708698 @default.
- W2123745142 cites W2045832449 @default.
- W2123745142 cites W2047988218 @default.
- W2123745142 cites W2049271296 @default.
- W2123745142 cites W2054362610 @default.
- W2123745142 cites W2056017024 @default.
- W2123745142 cites W2057820430 @default.
- W2123745142 cites W2058000339 @default.
- W2123745142 cites W2062359569 @default.
- W2123745142 cites W2062962009 @default.
- W2123745142 cites W2063298138 @default.
- W2123745142 cites W2063684370 @default.
- W2123745142 cites W2064421085 @default.
- W2123745142 cites W2065758000 @default.
- W2123745142 cites W2068492931 @default.
- W2123745142 cites W2069762113 @default.
- W2123745142 cites W2070304486 @default.
- W2123745142 cites W2071396517 @default.
- W2123745142 cites W2075728414 @default.
- W2123745142 cites W2076703003 @default.
- W2123745142 cites W2082847081 @default.
- W2123745142 cites W2086127120 @default.
- W2123745142 cites W2088151782 @default.
- W2123745142 cites W2092809703 @default.
- W2123745142 cites W2095138166 @default.
- W2123745142 cites W2096996607 @default.
- W2123745142 cites W2097488696 @default.
- W2123745142 cites W2097667256 @default.
- W2123745142 cites W2098100151 @default.
- W2123745142 cites W2101245680 @default.
- W2123745142 cites W2104299118 @default.
- W2123745142 cites W2110087431 @default.
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- W2123745142 cites W2133710866 @default.
- W2123745142 cites W2135731259 @default.
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- W2123745142 cites W2149845523 @default.
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- W2123745142 cites W2155118487 @default.
- W2123745142 cites W2155676778 @default.
- W2123745142 cites W2160504216 @default.
- W2123745142 cites W2162088045 @default.
- W2123745142 cites W2164613158 @default.
- W2123745142 cites W2166604768 @default.
- W2123745142 cites W2183803729 @default.
- W2123745142 cites W2199166367 @default.
- W2123745142 cites W4231077228 @default.
- W2123745142 cites W4239384318 @default.
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- W2123745142 doi "https://doi.org/10.1080/08958370701496202" @default.
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