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• W2123755308 abstract "Merkel cells are mechanosensitive skin cells whose production requires the basic helix-loop-helix transcription factor Atoh1. We induced ectopic Atoh1 expression in the skin of transgenic mice to determine whether Atoh1 was sufficient to create additional Merkel cells. In embryos, ectopic Atoh1 expression drove ectopic expression of the Merkel cell marker keratin 8 (K8) throughout the epidermis. Epidermal Atoh1 induction in adolescent mice similarly drove widespread K8 expression in glabrous skin of the paws, but in the whisker pads and body skin ectopic K8+ cells were confined to hair follicles and absent from interfollicular regions. Ectopic K8+ cells acquired several characteristics of mature Merkel cells in a time frame similar to that seen during postnatal development of normal Merkel cells. Although ectopic K8+ cell numbers decreased over time, small numbers of these cells remained in deep regions of body skin hair follicles at 3 months post-induction. In adult mice, greater numbers of ectopic K8+ cells were created by Atoh1 induction during anagen versus telogen and following disruption of Notch signaling by conditional deletion of Rbpj in the epidermis. Our data demonstrate that Atoh1 expression is sufficient to produce new Merkel cells in the epidermis, that epidermal cell competency to respond to Atoh1 varies by skin location, developmental age and hair cycle stage, and that the Notch pathway plays a key role in limiting epidermal cell competency to respond to Atoh1 expression." @default.
• W2123755308 created "2016-06-24" @default.
• W2123755308 creator A5001915648 @default.
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• W2123755308 creator A5027815542 @default.
• W2123755308 creator A5037774490 @default.
• W2123755308 creator A5061340743 @default.
• W2123755308 date "2015-01-01" @default.
• W2123755308 modified "2023-09-30" @default.
• W2123755308 title "Ectopic<i>Atoh1</i>expression drives Merkel cell production in embryonic, postnatal and adult epidermis" @default.
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• W2123755308 doi "https://doi.org/10.1242/dev.123141" @default.
• W2123755308 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4510865" @default.
• W2123755308 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26138479" @default.
• W2123755308 hasPublicationYear "2015" @default.
• W2123755308 type Work @default.
• W2123755308 sameAs 2123755308 @default.

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