Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123758151> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2123758151 endingPage "135" @default.
- W2123758151 startingPage "126" @default.
- W2123758151 abstract "Data from two large, community-based clinical trials that evaluated the efficacy of epoetin alfa in anemic cancer patients receiving chemotherapy were retrospectively analyzed to determine if clinical outcomes were different depending on whether chemotherapy was platinum- or nonplatinum-based.Patients received epoetin alfa 150-300 IU/kg (Glaspy: Study 1; n = 2,342) or 10,000-20,000 IU (Demetri: Study 2; n = 2,370) s.c. three times each week for 4 months. Efficacy end points were changes in transfusion requirements, hemoglobin (Hb) levels, and quality of life (QOL). A total of 4,298 out of 4,712 patients (platinum-based, n = 1,601; nonplatinum-based, n = 2,697), who both received chemotherapy and had available data, were eligible for this retrospective analysis.Baseline characteristics across groups were comparable with few exceptions, which were anticipated in view of the characteristics of the two different chemotherapy types. Decreases in transfusion requirements after 2, 3, and 4 months were significant, regardless of chemotherapy type. Mean increases in Hb level from baseline to final evaluation ranged from 1.6 g/dl to 2.0 g/dl across study groups and were significant, regardless of chemotherapy type. QOL, as measured by the Linear Analog Scale Assessment (LASA), improved significantly by 20%-43%, regardless of chemotherapy type, and improvements were associated with increases in Hb. Epoetin alfa was well tolerated in both studies, regardless of chemotherapy type.Treatment of anemic cancer patients with epoetin alfa results in significant reduction in transfusion requirements, increase in Hb levels, and improvements in QOL, regardless of whether the chemotherapy is platinum- or nonplatinum-based." @default.
- W2123758151 created "2016-06-24" @default.
- W2123758151 creator A5002614820 @default.
- W2123758151 creator A5060580923 @default.
- W2123758151 creator A5067297017 @default.
- W2123758151 creator A5080006341 @default.
- W2123758151 date "2002-04-01" @default.
- W2123758151 modified "2023-09-30" @default.
- W2123758151 title "Comparable Efficacy of Epoetin Alfa for Anemic Cancer Patients Receiving Platinum- and Nonplatinum-Based Chemotherapy: A Retrospective Subanalysis of Two Large, Community-Based Trials" @default.
- W2123758151 cites W1821554592 @default.
- W2123758151 cites W1867073577 @default.
- W2123758151 cites W1884165293 @default.
- W2123758151 cites W1885881044 @default.
- W2123758151 cites W1920419572 @default.
- W2123758151 cites W2015276413 @default.
- W2123758151 cites W2090741998 @default.
- W2123758151 cites W2094963379 @default.
- W2123758151 cites W2110612111 @default.
- W2123758151 cites W2120940824 @default.
- W2123758151 cites W2123365739 @default.
- W2123758151 cites W2163830215 @default.
- W2123758151 cites W2329804409 @default.
- W2123758151 cites W2809754341 @default.
- W2123758151 doi "https://doi.org/10.1634/theoncologist.7-2-126" @default.
- W2123758151 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11961196" @default.
- W2123758151 hasPublicationYear "2002" @default.
- W2123758151 type Work @default.
- W2123758151 sameAs 2123758151 @default.
- W2123758151 citedByCount "35" @default.
- W2123758151 countsByYear W21237581512012 @default.
- W2123758151 countsByYear W21237581512013 @default.
- W2123758151 countsByYear W21237581512014 @default.
- W2123758151 countsByYear W21237581512017 @default.
- W2123758151 countsByYear W21237581512018 @default.
- W2123758151 countsByYear W21237581512020 @default.
- W2123758151 countsByYear W21237581512021 @default.
- W2123758151 crossrefType "journal-article" @default.
- W2123758151 hasAuthorship W2123758151A5002614820 @default.
- W2123758151 hasAuthorship W2123758151A5060580923 @default.
- W2123758151 hasAuthorship W2123758151A5067297017 @default.
- W2123758151 hasAuthorship W2123758151A5080006341 @default.
- W2123758151 hasBestOaLocation W21237581511 @default.
- W2123758151 hasConcept C121608353 @default.
- W2123758151 hasConcept C126322002 @default.
- W2123758151 hasConcept C141071460 @default.
- W2123758151 hasConcept C143998085 @default.
- W2123758151 hasConcept C167135981 @default.
- W2123758151 hasConcept C2776164570 @default.
- W2123758151 hasConcept C2776694085 @default.
- W2123758151 hasConcept C2778248108 @default.
- W2123758151 hasConcept C535046627 @default.
- W2123758151 hasConcept C71924100 @default.
- W2123758151 hasConceptScore W2123758151C121608353 @default.
- W2123758151 hasConceptScore W2123758151C126322002 @default.
- W2123758151 hasConceptScore W2123758151C141071460 @default.
- W2123758151 hasConceptScore W2123758151C143998085 @default.
- W2123758151 hasConceptScore W2123758151C167135981 @default.
- W2123758151 hasConceptScore W2123758151C2776164570 @default.
- W2123758151 hasConceptScore W2123758151C2776694085 @default.
- W2123758151 hasConceptScore W2123758151C2778248108 @default.
- W2123758151 hasConceptScore W2123758151C535046627 @default.
- W2123758151 hasConceptScore W2123758151C71924100 @default.
- W2123758151 hasIssue "2" @default.
- W2123758151 hasLocation W21237581511 @default.
- W2123758151 hasLocation W21237581512 @default.
- W2123758151 hasOpenAccess W2123758151 @default.
- W2123758151 hasPrimaryLocation W21237581511 @default.
- W2123758151 hasRelatedWork W1041259088 @default.
- W2123758151 hasRelatedWork W1974188826 @default.
- W2123758151 hasRelatedWork W2112217407 @default.
- W2123758151 hasRelatedWork W2144140017 @default.
- W2123758151 hasRelatedWork W2397946790 @default.
- W2123758151 hasRelatedWork W2533558478 @default.
- W2123758151 hasRelatedWork W2926546306 @default.
- W2123758151 hasRelatedWork W3139593660 @default.
- W2123758151 hasRelatedWork W4236424420 @default.
- W2123758151 hasRelatedWork W2418834791 @default.
- W2123758151 hasVolume "7" @default.
- W2123758151 isParatext "false" @default.
- W2123758151 isRetracted "false" @default.
- W2123758151 magId "2123758151" @default.
- W2123758151 workType "article" @default.