Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123766064> ?p ?o ?g. }
- W2123766064 endingPage "284" @default.
- W2123766064 startingPage "274" @default.
- W2123766064 abstract "Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease that affects mainly females. What role the X chromosome plays in the disease has always been an intriguing question. In this study, we examined the genetic variants on the X chromosome through meta-analysis of two genome-wide association studies (GWAS) on SLE on Chinese Han populations. Prominent association signals from the meta-analysis were replicated in 4 additional Asian cohorts, with a total of 5373 cases and 9166 matched controls. We identified a novel variant in PRPS2 on Xp22.3 as associated with SLE with genome-wide significance (rs7062536, OR = 0.84, P = 1.00E-08). Association of the L1CAM-MECP2 region with SLE was reported previously. In this study, we identified independent contributors in this region in NAA10 (rs2071128, OR = 0.81, P = 2.19E-13) and TMEM187 (rs17422, OR = 0.75, P = 1.47E-15), in addition to replicating the association from IRAK1-MECP2 region (rs1059702, OR = 0.71, P = 2.40E-18) in Asian cohorts. The X-linked susceptibility variants showed higher effect size in males than that in females, similar to results from a genome-wide survey of associated SNPs on the autosomes. These results suggest that susceptibility genes identified on the X chromosome, while contributing to disease predisposition, might not contribute significantly to the female predominance of this prototype autoimmune disease." @default.
- W2123766064 created "2016-06-24" @default.
- W2123766064 creator A5001699296 @default.
- W2123766064 creator A5004488408 @default.
- W2123766064 creator A5009185201 @default.
- W2123766064 creator A5011092040 @default.
- W2123766064 creator A5011859890 @default.
- W2123766064 creator A5012653703 @default.
- W2123766064 creator A5018516395 @default.
- W2123766064 creator A5021765106 @default.
- W2123766064 creator A5023898955 @default.
- W2123766064 creator A5027121380 @default.
- W2123766064 creator A5027962352 @default.
- W2123766064 creator A5032650852 @default.
- W2123766064 creator A5033947419 @default.
- W2123766064 creator A5034611795 @default.
- W2123766064 creator A5036454981 @default.
- W2123766064 creator A5037615314 @default.
- W2123766064 creator A5039335550 @default.
- W2123766064 creator A5039496582 @default.
- W2123766064 creator A5040973142 @default.
- W2123766064 creator A5042806799 @default.
- W2123766064 creator A5044757881 @default.
- W2123766064 creator A5047546336 @default.
- W2123766064 creator A5048807640 @default.
- W2123766064 creator A5049991611 @default.
- W2123766064 creator A5051283655 @default.
- W2123766064 creator A5055197068 @default.
- W2123766064 creator A5056424317 @default.
- W2123766064 creator A5057503770 @default.
- W2123766064 creator A5059736647 @default.
- W2123766064 creator A5064660745 @default.
- W2123766064 creator A5064932018 @default.
- W2123766064 creator A5065575431 @default.
- W2123766064 creator A5070748655 @default.
- W2123766064 creator A5072149062 @default.
- W2123766064 creator A5072932253 @default.
- W2123766064 creator A5073058414 @default.
- W2123766064 creator A5075713847 @default.
- W2123766064 creator A5082439001 @default.
- W2123766064 creator A5083162091 @default.
- W2123766064 creator A5083434138 @default.
- W2123766064 creator A5086664284 @default.
- W2123766064 creator A5086812672 @default.
- W2123766064 creator A5087155263 @default.
- W2123766064 creator A5087416916 @default.
- W2123766064 creator A5088714182 @default.
- W2123766064 creator A5089074499 @default.
- W2123766064 creator A5090069208 @default.
- W2123766064 creator A5090072859 @default.
- W2123766064 creator A5002777414 @default.
- W2123766064 creator A5032721045 @default.
- W2123766064 creator A5077931303 @default.
- W2123766064 date "2014-08-22" @default.
- W2123766064 modified "2023-10-14" @default.
- W2123766064 title "Meta-analysis of GWAS on two Chinese populations followed by replication identifies novel genetic variants on the X chromosome associated with systemic lupus erythematosus" @default.
- W2123766064 cites W1535914077 @default.
- W2123766064 cites W1567305408 @default.
- W2123766064 cites W1570853396 @default.
- W2123766064 cites W1964120320 @default.
- W2123766064 cites W1965381235 @default.
- W2123766064 cites W1970650235 @default.
- W2123766064 cites W1978449131 @default.
- W2123766064 cites W1987054275 @default.
- W2123766064 cites W1996626475 @default.
- W2123766064 cites W1997102398 @default.
- W2123766064 cites W2020958409 @default.
- W2123766064 cites W2025537613 @default.
- W2123766064 cites W2031580483 @default.
- W2123766064 cites W2038243216 @default.
- W2123766064 cites W2045286317 @default.
- W2123766064 cites W2049977668 @default.
- W2123766064 cites W2051536567 @default.
- W2123766064 cites W2052803753 @default.
- W2123766064 cites W2053899581 @default.
- W2123766064 cites W2061471228 @default.
- W2123766064 cites W2073839280 @default.
- W2123766064 cites W2076735703 @default.
- W2123766064 cites W2080040722 @default.
- W2123766064 cites W2089356048 @default.
- W2123766064 cites W2097986534 @default.
- W2123766064 cites W2104772150 @default.
- W2123766064 cites W2104902006 @default.
- W2123766064 cites W2106399339 @default.
- W2123766064 cites W2133520037 @default.
- W2123766064 cites W2147169794 @default.
- W2123766064 cites W2149791927 @default.
- W2123766064 cites W2156543902 @default.
- W2123766064 cites W2157352746 @default.
- W2123766064 cites W2157752701 @default.
- W2123766064 cites W2160371448 @default.
- W2123766064 cites W2162530578 @default.
- W2123766064 cites W2168909456 @default.
- W2123766064 doi "https://doi.org/10.1093/hmg/ddu429" @default.
- W2123766064 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25149475" @default.
- W2123766064 hasPublicationYear "2014" @default.
- W2123766064 type Work @default.
- W2123766064 sameAs 2123766064 @default.