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• W2123767698 abstract "A novel inhibitor-resistant TEM (IRT) beta-lactamase was detected in an Escherichia coli isolate resistant to amoxicillin-clavulanate and susceptible to cephalothin. The substrate and inhibitor profiles of this beta-lactamase were similar to those of IRT-1 and IRT-2. The novel IRT's bla gene was sequenced, and the deduced amino acid sequence showed the amino acid replacement Arg for His-244 of the TEM-1 sequence. Substitutions for Arg-244 have been reported in three TEM-1 mutants: IRT-1 (which corresponds to TEM-31) (Cys), IRT-2/TEM-30 (Ser), and TEM-41 (Thr). We designated this novel beta-lactamase, which corresponds to TEM-51, IRT-15." @default.
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• W2123767698 date "1997-11-01" @default.
• W2123767698 modified "2023-09-27" @default.
• W2123767698 title "Inhibitor-resistant TEM (IRT) beta-lactamases with different substitutions at position 244" @default.
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• W2123767698 doi "https://doi.org/10.1128/aac.41.11.2547" @default.
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