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- W2123786197 abstract "Arterial smooth muscle cells (SMCs) play a major role in atherosclerosis and restenosis. Differential display was used to compare transcription profiles of synthetic SMCs to proliferating rat cultured SMC line. An isolated cDNA band (6A3-5) was shown by northern (7 kb) to be upregulated in the proliferating cell line. A rat tissue northern showed differential expression of this gene in different tissues. Using 5’ RACE and screening of a rat brain library, part of the cDNA was cloned and sequenced (5.4 kb). Sequence searches showed important similarities with a new family of transcription factors, bearing ARID motifs. A polyclonal antibody was raised and showed a protein band of 175 kd, which is localized intracellularly. We also showed that 6A3-5 is upregulated in dedifferentiated SMC (P9) in comparison to contractile SMC ex vivo (P0). This work describes cloning, structural, and functional characterization of a new early gene involved in SMC phenotype modulation." @default.
- W2123786197 created "2016-06-24" @default.
- W2123786197 creator A5026001986 @default.
- W2123786197 creator A5081828105 @default.
- W2123786197 creator A5088635360 @default.
- W2123786197 date "2005-01-01" @default.
- W2123786197 modified "2023-10-16" @default.
- W2123786197 title "Identification, Structural, and Functional Characterization of a New Early Gene (6A3-5, 7 kb): Implication in the Proliferation and Differentiation of Smooth Muscle Cells" @default.
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- W2123786197 doi "https://doi.org/10.1155/jbb.2005.254" @default.
- W2123786197 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1224700" @default.
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- W2123786197 hasPublicationYear "2005" @default.
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