Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123795043> ?p ?o ?g. }
- W2123795043 endingPage "83" @default.
- W2123795043 startingPage "77" @default.
- W2123795043 abstract "This review focuses on the emerging evidence that reactive oxygen species (ROS) derived from glucose metabolism, such as H(2)O(2), act as metabolic signaling molecules for glucose-stimulated insulin secretion (GSIS) in pancreatic beta-cells. Particular emphasis is placed on the potential inhibitory role of endogenous antioxidants, which rise in response to oxidative stress, in glucose-triggered ROS and GSIS. We propose that cellular adaptive response to oxidative stress challenge, such as nuclear factor E2-related factor 2 (Nrf2)-mediated antioxidant induction, plays paradoxical roles in pancreatic beta-cell function. On the one hand, induction of antioxidant enzymes protects beta-cells from oxidative damage and possible cell death, thus minimizing oxidative damage-related impairment of insulin secretion. On the other hand, the induction of antioxidant enzymes by Nrf2 activation blunts glucose-triggered ROS signaling, thus resulting in reduced GSIS. These two premises are potentially relevant to impairment of beta-cells occurring in the late and early stage of Type 2 diabetes, respectively. In addition, we summarized our recent findings that persistent oxidative stress due to absence of uncoupling protein 2 activates cellular adaptive response which is associated with impaired pancreatic beta-cell function." @default.
- W2123795043 created "2016-06-24" @default.
- W2123795043 creator A5001442165 @default.
- W2123795043 creator A5002172845 @default.
- W2123795043 creator A5006905654 @default.
- W2123795043 creator A5021058678 @default.
- W2123795043 creator A5026001980 @default.
- W2123795043 creator A5072641478 @default.
- W2123795043 creator A5082540496 @default.
- W2123795043 creator A5082833865 @default.
- W2123795043 date "2010-04-01" @default.
- W2123795043 modified "2023-09-23" @default.
- W2123795043 title "ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function" @default.
- W2123795043 cites W1529592271 @default.
- W2123795043 cites W1562122315 @default.
- W2123795043 cites W1594539479 @default.
- W2123795043 cites W1874751834 @default.
- W2123795043 cites W1921965616 @default.
- W2123795043 cites W1968262859 @default.
- W2123795043 cites W1968276731 @default.
- W2123795043 cites W1973011634 @default.
- W2123795043 cites W1975321257 @default.
- W2123795043 cites W1975515886 @default.
- W2123795043 cites W1979155817 @default.
- W2123795043 cites W1985776151 @default.
- W2123795043 cites W1986399270 @default.
- W2123795043 cites W1987182674 @default.
- W2123795043 cites W1987790381 @default.
- W2123795043 cites W1991238715 @default.
- W2123795043 cites W1992678387 @default.
- W2123795043 cites W1994201341 @default.
- W2123795043 cites W1994914276 @default.
- W2123795043 cites W1995095187 @default.
- W2123795043 cites W1996826558 @default.
- W2123795043 cites W2004757124 @default.
- W2123795043 cites W2004815940 @default.
- W2123795043 cites W2006094849 @default.
- W2123795043 cites W2007324390 @default.
- W2123795043 cites W2008581655 @default.
- W2123795043 cites W2010290591 @default.
- W2123795043 cites W2013044163 @default.
- W2123795043 cites W2013339696 @default.
- W2123795043 cites W2015892691 @default.
- W2123795043 cites W2016207732 @default.
- W2123795043 cites W2017280433 @default.
- W2123795043 cites W2021108639 @default.
- W2123795043 cites W2021809018 @default.
- W2123795043 cites W2022183036 @default.
- W2123795043 cites W2028212562 @default.
- W2123795043 cites W2028690937 @default.
- W2123795043 cites W2030867249 @default.
- W2123795043 cites W2034244149 @default.
- W2123795043 cites W2036573181 @default.
- W2123795043 cites W2042769297 @default.
- W2123795043 cites W2044437167 @default.
- W2123795043 cites W2046692619 @default.
- W2123795043 cites W2051505012 @default.
- W2123795043 cites W2052325227 @default.
- W2123795043 cites W2053126056 @default.
- W2123795043 cites W2054360558 @default.
- W2123795043 cites W2058012195 @default.
- W2123795043 cites W2059240823 @default.
- W2123795043 cites W2059467226 @default.
- W2123795043 cites W2061354090 @default.
- W2123795043 cites W2065326103 @default.
- W2123795043 cites W2069185580 @default.
- W2123795043 cites W2071250916 @default.
- W2123795043 cites W2074396059 @default.
- W2123795043 cites W2079230681 @default.
- W2123795043 cites W2081748503 @default.
- W2123795043 cites W2083550082 @default.
- W2123795043 cites W2085664820 @default.
- W2123795043 cites W2085977860 @default.
- W2123795043 cites W2087282685 @default.
- W2123795043 cites W2088869602 @default.
- W2123795043 cites W2091990176 @default.
- W2123795043 cites W2095816719 @default.
- W2123795043 cites W2096261918 @default.
- W2123795043 cites W2097155911 @default.
- W2123795043 cites W2098689751 @default.
- W2123795043 cites W2101651261 @default.
- W2123795043 cites W2101870887 @default.
- W2123795043 cites W2102258234 @default.
- W2123795043 cites W2104645520 @default.
- W2123795043 cites W2107485860 @default.
- W2123795043 cites W2108212852 @default.
- W2123795043 cites W2109069544 @default.
- W2123795043 cites W2109286159 @default.
- W2123795043 cites W2114041992 @default.
- W2123795043 cites W2123273404 @default.
- W2123795043 cites W2124524961 @default.
- W2123795043 cites W2124898423 @default.
- W2123795043 cites W2125285674 @default.
- W2123795043 cites W2128167237 @default.
- W2123795043 cites W2128342607 @default.
- W2123795043 cites W2128569391 @default.
- W2123795043 cites W2131757911 @default.
- W2123795043 cites W2134345431 @default.