Matches in SemOpenAlex for { <https://semopenalex.org/work/W2123797367> ?p ?o ?g. }
- W2123797367 endingPage "1361" @default.
- W2123797367 startingPage "1351" @default.
- W2123797367 abstract "It is widely assumed that genes that influence variation in skin and hair pigmentation are under selection. To date, the melanocortin 1 receptor (MC1R) is the only gene identified that explains substantial phenotypic variance in human pigmentation. Here we investigate MC1R polymorphism in several populations, for evidence of selection. We conclude that MC1R is under strong functional constraint in Africa, where any diversion from eumelanin production (black pigmentation) appears to be evolutionarily deleterious. Although many of the MC1R amino acid variants observed in non-African populations do affect MC1R function and contribute to high levels of MC1R diversity in Europeans, we found no evidence, in either the magnitude or the patterns of diversity, for its enhancement by selection; rather, our analyses show that levels of MC1R polymorphism simply reflect neutral expectations under relaxation of strong functional constraint outside Africa." @default.
- W2123797367 created "2016-06-24" @default.
- W2123797367 creator A5000016106 @default.
- W2123797367 creator A5001629532 @default.
- W2123797367 creator A5013675331 @default.
- W2123797367 creator A5029430064 @default.
- W2123797367 creator A5040843852 @default.
- W2123797367 creator A5054569153 @default.
- W2123797367 creator A5070906741 @default.
- W2123797367 creator A5071084545 @default.
- W2123797367 creator A5083469770 @default.
- W2123797367 creator A5086841100 @default.
- W2123797367 creator A5087478187 @default.
- W2123797367 date "2000-04-01" @default.
- W2123797367 modified "2023-10-16" @default.
- W2123797367 title "Evidence for Variable Selective Pressures at MC1R" @default.
- W2123797367 cites W1502061430 @default.
- W2123797367 cites W1516569903 @default.
- W2123797367 cites W1561726411 @default.
- W2123797367 cites W1920973730 @default.
- W2123797367 cites W1974523504 @default.
- W2123797367 cites W1976472164 @default.
- W2123797367 cites W1980674207 @default.
- W2123797367 cites W1980704858 @default.
- W2123797367 cites W1981605211 @default.
- W2123797367 cites W1982527304 @default.
- W2123797367 cites W1982603712 @default.
- W2123797367 cites W1987752391 @default.
- W2123797367 cites W1993253894 @default.
- W2123797367 cites W1996887960 @default.
- W2123797367 cites W2022005040 @default.
- W2123797367 cites W2028130288 @default.
- W2123797367 cites W2035653117 @default.
- W2123797367 cites W2049156270 @default.
- W2123797367 cites W2051112657 @default.
- W2123797367 cites W2061772094 @default.
- W2123797367 cites W2080766161 @default.
- W2123797367 cites W2082765461 @default.
- W2123797367 cites W2091161222 @default.
- W2123797367 cites W2091836794 @default.
- W2123797367 cites W2104817314 @default.
- W2123797367 cites W2116893702 @default.
- W2123797367 cites W2128197945 @default.
- W2123797367 cites W2128725994 @default.
- W2123797367 cites W2133235730 @default.
- W2123797367 cites W2133585817 @default.
- W2123797367 cites W2146638375 @default.
- W2123797367 cites W2163600007 @default.
- W2123797367 cites W2164258425 @default.
- W2123797367 cites W2167278223 @default.
- W2123797367 cites W2169197798 @default.
- W2123797367 cites W4210633230 @default.
- W2123797367 cites W4249105500 @default.
- W2123797367 cites W4254753097 @default.
- W2123797367 cites W4377559846 @default.
- W2123797367 cites W632712882 @default.
- W2123797367 doi "https://doi.org/10.1086/302863" @default.
- W2123797367 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1288200" @default.
- W2123797367 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10733465" @default.
- W2123797367 hasPublicationYear "2000" @default.
- W2123797367 type Work @default.
- W2123797367 sameAs 2123797367 @default.
- W2123797367 citedByCount "354" @default.
- W2123797367 countsByYear W21237973672012 @default.
- W2123797367 countsByYear W21237973672013 @default.
- W2123797367 countsByYear W21237973672014 @default.
- W2123797367 countsByYear W21237973672015 @default.
- W2123797367 countsByYear W21237973672016 @default.
- W2123797367 countsByYear W21237973672017 @default.
- W2123797367 countsByYear W21237973672018 @default.
- W2123797367 countsByYear W21237973672019 @default.
- W2123797367 countsByYear W21237973672020 @default.
- W2123797367 countsByYear W21237973672021 @default.
- W2123797367 countsByYear W21237973672022 @default.
- W2123797367 countsByYear W21237973672023 @default.
- W2123797367 crossrefType "journal-article" @default.
- W2123797367 hasAuthorship W2123797367A5000016106 @default.
- W2123797367 hasAuthorship W2123797367A5001629532 @default.
- W2123797367 hasAuthorship W2123797367A5013675331 @default.
- W2123797367 hasAuthorship W2123797367A5029430064 @default.
- W2123797367 hasAuthorship W2123797367A5040843852 @default.
- W2123797367 hasAuthorship W2123797367A5054569153 @default.
- W2123797367 hasAuthorship W2123797367A5070906741 @default.
- W2123797367 hasAuthorship W2123797367A5071084545 @default.
- W2123797367 hasAuthorship W2123797367A5083469770 @default.
- W2123797367 hasAuthorship W2123797367A5086841100 @default.
- W2123797367 hasAuthorship W2123797367A5087478187 @default.
- W2123797367 hasBestOaLocation W21237973671 @default.
- W2123797367 hasConcept C104317684 @default.
- W2123797367 hasConcept C127716648 @default.
- W2123797367 hasConcept C154945302 @default.
- W2123797367 hasConcept C182843373 @default.
- W2123797367 hasConcept C41008148 @default.
- W2123797367 hasConcept C54355233 @default.
- W2123797367 hasConcept C78458016 @default.
- W2123797367 hasConcept C81917197 @default.
- W2123797367 hasConcept C86803240 @default.
- W2123797367 hasConceptScore W2123797367C104317684 @default.