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- W2123801665 abstract "Objective: The objective of this study is to test diuretic effect of ethanol extract of P. acidus leaves in female Wistar rats using modification of Lipschitz method. Methods: The doses of the extract were 22.5, 45 and 90 mg/kg bw. Parameter of diuretic effect was cumulative urine volume during 6 and 24 hours after administration of the extract. Sodium and potassium level in urine were analyzed using atomic absorption spectrophotometry (AAS). The results were analyzed with Student-t test. Results: The ethanol extracts of P. acidus at doses of 22.5, 45, and 90 mg/kg bw could accelerate the urinary in rats since 60 minutes after oral administration compared to the control and furosemide 3.6 mg/kg bw (P<0.05). The level of sodium on 24 hour urine of the ethanol extracts of P. acidus at doses 22.5 and 45 mg/kg bw significantly higher than control group (P<0.05), but significantly lower than furosemide 3.6 mg/kg bw (P<0.05). The level of potassium on 24 hour urine of the ethanol extracts of P. acidus at doses 45 and 90 mg/kg bw significantly higher than control group (P<0.05), but significantly lower than furosemide 3.6 mg/kg bw (P<0.05). Conclusion: It can be concluded that the ethanol extract of P. acidus at doses of 22.5 mg/kg bw, 45 mg/kg bw and 90 mg/kg bw had significantly diuretic and saluretic effect compared to control group (P<0.05), but significantly less than furosemid 3.6 mg/kg bw (P<0.05)." @default.
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- W2123801665 date "2014-11-11" @default.
- W2123801665 modified "2023-09-23" @default.
- W2123801665 title "DIURETIC EFFECT OF THE ETHANOL EXTRACTS OF PHYLLANTHUS ACIDUS L (SKEELS) LEAVES IN WISTAR RATS" @default.
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